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Gout Arthritis
Disusun Oleh :
SORIA PUTU PRATIWI
(12100112032)
SMF RADIOLOGI
RSUD AL-IHSAN BANDUNG 2015
Definisi Gout
Merupakan penyakit dengan deposisi
kristal sodium urate monohydrate di
membran synovial, articular cartilage,
ligaments, dan bursae yang mengakibatkan
destruksi dari cartilage.
Mekanisme Gout
Gangguan metabolisme purin
Deposisi kristal Sodium monourate di
kartilage, synovium, periarticular, dan
jaringan subkutan.
Deposisi asam urat di artikular manapun.
Epidemiologi Gout
- > 40 th
- males > females
- > at 1st MTP joint
- usually not seen until 6-12 years after initial attack
- present in 50% of inflicted patients
Etiologi Gout
Idiopathic Gout
- M:F = 20:1
- Overproduction of uric acid
- Abnormality of renal urate excretion
Secondary Gout
- Rarely cause for radiographically apparent disease
- Myeloproliferative disorders (e.g. polycythemia vera, leukemia, lymphoma,
multiple myeloma)
- Blood dyscrasias
- Myxedema, hyperparathyroidism
- Chronic renal failure
- Glycogen storage disease
- Myocardial infarction
- Lead poisoning
Lokasi Gout
Sendi :
◦ Tangan dan kaki (Sendi MTP pertama sering terkena = podagra),
maupun pergelangannya.
◦ Carpometacarpal compartment pada knee, shoulder,
hip, sacroiliac joint