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» portalnce o f
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p h a rm a c o k in e tic p rin c ip le s c a n
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/ s u c c e s s a n d re d u c e th e o c c u rr e n c e o f
a d v e rs e d ru g e ffe c ts in th e b o d y .

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 Pha rm a c o k in e tic s

= C h a ro c fe ń s tic s o f D r u g th a t p re d ic ts o v a ila b lliľ y a f s ite s o f

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 = M o n y d ru g s a re w e a k a c id s o r b a se s th a i a re p re s e n t
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s p e e le s .

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c e ll m e m b ra n e

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in flu e its ro te o fa b so rp tio n th ro u g h

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s tim a c h pH : 3 4 In te s ï in o ıP H : 8 -

h p H is re o dđ
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D R U G A B S O R P T IO N ,

ßï O A V A ï LA B ILIT Y
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A N D R O U T E S O F A D M IN IS T R A TIO N

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= O N
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fa c llM a t e d d lf 【
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gra dı en t g r a d ie n t
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寧 島鹼 阁 国道 唧 塒 印壮卿卅 刨餬 M 姻
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 ßS O R P T IO N
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= M o s t d ru g s a b d fr o m th e
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= M o s t d ru g s a b s o r b e d fr o m th e
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liv e r b e fo
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in to th e g e n e r a l c irc u la tio n .

th e s y s te m ic c kc u la tio n .

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 O R A L A D M IN S T R A T IO N
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g a s tr ic
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P TR A N S D E R M A L A B S O R F

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e n ï th e ra py
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십 自 ん园 区きら ー ― ―

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 P A R E M E R A L A D M JN IS TR A TIO N
=
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Ļ C N S & C E R E B R 0 5 ĦN A L F L D

H H -t
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 C N S & C E R E B R O S P IN A L F L U ID {C SF)
7

= D ru g p e n e h a tio n d e p e n ds o n
tr o n s c e lł
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o p h ilic a d ru g th e m , o re
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