dA

=−( K 1+ K 2 ) . A ( t )
dt
dP
=K 2 . A ( t )−K 3 . P ( t )
dt
dG
=K 1 . A ( t )+ K 3 . P ( t )
dt

1ª EDO:

dA
=−( K 1+ K 2 ) .dt
A
ln ( A )−C=(−K 1 + K 2 ) . t

ln ( A )=−( K 1 + K 2 ) . t+C
−( K 1 +K 2) .t
A ( t )=C . e
t=0 , A ( 0 )=130,43
−( K 1+ K 2 ). t
A ( t )=130,43. e
t = 30s
−30 ( K 1+ K 2 )
118,66=130,43.e

K=
ln ( 118,66
130,43 )
−30
K= K 1+ K 2=0,00315248

2ª EDO Por operadores diferenciais:

dP
=K 2 . A ( t )−K 3 . P ( t )
dt

D . P=K 2 . A ( t )−K 3 . P ( t )

D . P+ K 3 . P=K 2 . A
 P ( D+ K 3 )=K 2 . A (eq 1)

D . P ( D+ K 3 ) =K 2 D . A

D . P ( D+ K 3 ) =−K 2 ( K 1+ K 2 ) . A

( D+ K 3 )
D.P =−K 2 . A (eq 2)
( K1+ K2)

( D+ K 3 )
D.P + P ( D+ K 3 ) =0
( K1+ K2)

P D.
( ( D+ K 3 )
( K 1+ K 2 )
+ ( D+ K 3 ) =0
)
P
(( ( D
K 1+ K 2 ) )
+1 ( D+ K 3 ) =0
)
D+ K 3=0

D=−K 3

D
+1=0
( K 1+ K 2 )
D=−( K 1+ K 2 )
− ( K 1 +K 2) t
P ( t ) =C0 . e−K .t +C 1 . e
3

0=C0. 1+C 1. 1

C 0=−C 1

P ( t ) =C1 ( e )
− ( K 1 +K 2) t −K 3 .t
−e
Derivando P(t):

dP
=C 1 (− ( K 1+ K 2 ) e ( + K3)
− K + K )t 1 2

dt
Isso será igual à equação original:

dP
=K 2 . A ( t )−K 3 . P ( t )=C 1 (−( K 1 + K 2 ) e ( )
− K +K )t −K .t
+ K3 e 1 2 3

dt

K 2 .(130,43. e
−( K 1+ K 2 ). t
)−K 3 .C 1 ( e
− ( K 1 +K 2) t
−e−K 3 .t
) =C 1 (−( K 1+ K 2 ) e−( K + K )t + K 3 e−K . t )
1 2 3

K 2 .( C 0. e )=C 1 (−( K 1 + K 2 ) e−( K +K ) t + K 3 e− K .t ) + K 3 . C1 ( e−( K +K ) t −e−K .t )

− ( K 1 +K 2) .t 1 2 3 1 2 3

K2 .(C0. e )
− ( K 1 +K 2) .t

=C 1
(− ( K 1 + K 2) e − ( K 1 + K 2) t
+ K 3 e−K . t )+ K 3 . ( e
3
− ( K 1+ K 2 ) t
−e− K .t )
3

C0. K2
=C 1
K 3− ( K 1 + K 2 )

Então:

C0 . K 2
.(e −e− K .t )
− ( K 1 + K 2) t
P (t )= 3

K 3 −( K 1 + K 2 )

−( K 1+ K 2 ). t
A ( t )=130,43. e

P ( t ) =C1 ( e )
− ( K 1 +K 2) t
−e−K 3 .t

dG
=K 1 . A ( t )+ K 3 . P ( t )
dt

G ( t ) −G 0=∫ K 1 . A ( t ) + K 3 . P ( t ) dt
 G ( t ) −G 0=∫ K 1 .130,43. e + K 3 .C 1 ( e ) dt
− ( K 1 +K 2) .t − ( K 1+ K 2 ) t −K 3 . t
−e

( )
−( K 1+ K 2 ). t −( K 1+ K 2 ) t − K 3 .t
e e e
G ( t ) =K 1 . C 0 . + K 3 . C1 − +G 0
−( K 1 + K 2 ) −( K 1 + K 2 ) −K 3

Como a concentração final será C0:

( )
− ( K 1+ K 2 ) .t − ( K 1+ K 2 ) t − K 3 .t
e e e
lim K 1 .C 0 . + K3. C1 − +G 0=G 0
n→∞ −( K 1 + K 2 ) −( K 1+ K 2) −K 3

G0=C 0

( )
−( K 1+ K 2 ). t − ( K 1+ K 2 ) t − K 3 .t
e e e
G ( t ) =K 1 . C 0 . + K 3 . C1 − +C 0
−( K 1 + K 2 ) −( K 1 + K 2 ) −K 3

O modelo de G(t) pode ser operado para ficar com uma forma mais natural:

( )
−( K 1+ K 2 ). t − ( K 1+ K 2 ) t − K 3 .t
e e e
G ( t ) =K 1 . C 0 . + K 3 . C1 − +C 0
−( K 1 + K 2 ) −( K 1 + K 2 ) −K 3

( )
−( K + K ). t − ( K +K ) t −K . t
e 1 2
C0. K2 e e 1 2 3

G ( t ) =K 1 . C 0 . + K 3. − +C 0
−( K 1 + K 2 ) K 3−( K 1 + K 2 ) −( K 1 + K 2 ) −K 3

( ( ) )
− K .t −( K + K )t − ( K 1+ K 2 ) .t
K2 K3 e e K1 e 3 1 2

G ( t ) =C0 1+ − −
K 3− ( K 1+ K 2 ) K 3 K 1+ K 2 K1+ K2

Colocando -e-(k1+k2)t /(k1+k2)em evidência:

( ( ))
−K 3 . t
−( K + K ). t
K2 e e K2 K3 1 2

G ( t ) =C0 1+ − K1+
K 3−K 1−K 2 K 1 + K 2 K 3−K 1−K 2

− ( K 1 +K 2) .t
A ( t )=C 0 . e
C0 . K 2
.(e )
− ( K 1 + K 2) t − K 3 .t
P (t )= −e
K 3 −( K 1 + K 2 )

( ( ))
−K 3 . t
−( K + K ). t
K2 e e K2 K3 1 2

G ( t ) =C0 1+ − K1+
K 3−K 1−K 2 K 1 + K 2 K 3−K 1−K 2
Manipulações para obter K1+K2, e K3 no excel

K2
P (t)= . ( A (t)−C 0 e−K 3 .t
)
K 3 −( K 1 + K 2 )

K2
P ( a) = . ( A ( a )−C 0 e−K . a ) 3

K 3 − ( K 1+ K 2 )

K2
P(b)= . ( A (b)−C 0 e−K . b ) 3

K 3 −( K 1 + K 2 )

P ( a) ( e ( )
−e−K . a )
− K 1+ K 2 .a 3

=
P ( b ) ( e−( K + K ) .b−e−K . b )
1 2 3

P ( a) ( e )
− ( K 1+ K 2 ) .b −K 3 .b
−e
=( e )
− ( K 1+ K 2 ) .a −K 3 . a
−e
P (b)

P ( a) ( e ( )
( )
− K 1+ K 2 ) .b
− ( K 1+ K 2 ) .a −K 3 . b P ( a )−P ( b )
−e =e
P (b ) P ( b)

P ( a)( e ) −P ( b ) e−( K + K ) .a
− ( K 1+ K 2 ) .b 1 2
− K 3 .b
=e
P ( a ) −P ( b )

( P (a )(e ) −P ( b ) e−( K + K ). a
)
− ( K 1+ K 2 ) .b 1 2

ln
P ( a )−P ( b )
K 3=
−b

K2
. ( A (b)−C 0 e )
−K 3 . b
P(b)=
K 3 −( K 1 + K 2 )
 P ( b ) . ( K 3− ( K 1 + K 2 ) )
K 2=
( A ( b )−C 0 e−K . b )
3

https://www.desmos.com/calculator/jtbr9uxvwk

https://colab.research.google.com/drive/1bUMPnoEtuQKqmVCRzvNsNwGx3RBXJS5H?
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Mínimos quadrados

Função de custo J:

J ( K 1 , K 2 , K 3 )=∑ ( A ( t ) −A i (t ) ) + ( P ( t )−Pi ( t ) ) + ( G ( t )−Gi ( t ))

2 2 2

J ( K 1 , K 2 , K 3 )=∑ ( A− A i) 2+ ( P−Pi )2 + ( G−Gi ) 2

Removendo os (t) para simplificar a escrita, e realizando os quadrados:

J ( K 1 , K 2 , K 3 )=∑ ( A2− A . Ai + Ai2 ) + ( P2−P . Pi + Pi2 ) + ( G 2−G .Gi +Gi2 )

Agora vem a parte complicada, que são as derivadas parciais de J:

( ∂∂KJ , ∂∂KJ , ∂∂KJ )=( 0,0,0)

1 2 3

∂J
∂K1 [
=∑ 2 ( A− A i)
∂A
∂ K1
+ ( P−Pi )
∂P
∂ K1
+ ( G−Gi )
∂G
∂ K1 ]
∂J
∂K1 [
=∑ 2 ( A− A i)
∂A
∂ K1
+ ( P−Pi )
∂P
∂ K1
+ ( G−Gi )
∂G
∂ K1 ]
∂A
=−t . A
∂K1

∂P C0. K2 C0. K2
. (e ( −e− K .t ) + . (−t . e ( )
− K +K ) t − K +K )t
= 1 2 3 1 2

∂ K 1 [ K −( K + K ) ]
3 1 2
2
K 3 − ( K 1 + K 2 )

( (
− ( K 1+ K 2 ) .t − ( K 1+ K 2 ) .t
( K 1 + K 2 ) −e
( )
−K 3 .t − ( K + K ) .t
∂G K2 e −t . e K2 K3 e 1 2
K2 K 3
=C 0 − K1+ − 1+
∂K1 ( K 3−K 1−K 2 )
2
( K1+ K2)
2
K 3−K 1−K 2 K1+ K2 ( K 3−K 1−