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Department of 4eneral Practice and +ealth Ser(ices Research, 'ni(ersitB Medical +ospital,
'ni(ersitB of +eidelberg, @ossstrasse ?, ;JD?C +eidelberg, 4ermanB.
antonius.schneiderPmed.uni%heidelberg.de
BA!H4RO'KD AKD A#MS3 Despite occasional positi(e reports on the efficacB of acupuncture
=A!> on functions of the gastrointestinal tract, there is no conclusi(e e(idence that A! is effecti(e
in the treatment of irritable boFel sBndrome =#BS>. PA#8KS AKD M8+ODS3 FortB three
patients Fith #BS according to the Rome ## criteria Fere randomlB assigned to recei(e either A! =n
O ??> or sham acupuncture =SA!> =n O ?D> using the so%called QStreitberger needleQ. reatment
duration Fas DC sessions Fith an a(erage of tFo A! sessions per FeeG. he primarB end point Fas
impro(ement in /ualitB of life =AOL> using the functional digesti(e diseases /ualitB of life
/uestionnaire =FDDAL> and a general /ualitB of life /uestionnaire =SF%5;>, compared Fith baseline
assessments. AOL measurements Fere repeated three months after treatment. R8S'LS3 Both the
A! and SA! groups impro(ed significantlB in global AOL, as assessed bB the FDDAL, at the end
of treatment =p O C.C??>, Fith no differences betFeen the groups. SF%5; Fas insensiti(e to these
changes =eMcept for pain>. his effect Fas partiallB re(ersed three months later. Post hoc
comparison of responders and non%responders in both groups combined re(ealed a significant
prediction of the placebo response bB tFo subscales of the FDDAL =sleep, coping> =F O ;.I6;, p O
C.CC5> in a stepFise regression model. !OK!L'S#OKS3 Acupuncture in #BS is primarilB a placebo
response. Based on the small differences found betFeen the A! and SA! groups, a studB including
9;; patients Fould be necessarB to pro(e the efficacB of A! o(er SA!. he placebo response maB
be predicted bB high coping capacitB and loF sleep /ualitB in indi(idual patients.
:orld * 4astroenterol. ?CC9 *ul D62DD=?;>36C6C%6.
Acupuncture for irritable boel s!ndrome: a blinded placebo#
controlled trial"
Forbes A , *acGson S, :alter !, Auraishi S, *acBna M, Pitcher M.
St MarG1s +ospital, :atford Road, +arroF +AD 5'*, 'nited Hingdom. lastair.forbesPic.ac.uG
A#M3 #rritable boFel sBndrome =#BS> is a common disorder and manB patients fail to find ade/uate
relief from con(entional therapies for their sBmptoms. his studB tests the claim that acupuncture is
effecti(e for a maLoritB of these patients. M8+ODS3 A prospecti(e, blinded, sham acupuncture%
controlled trial of traditional !hinese acupuncture Fas performed at a single postgraduate teaching
hospital in 8urope. SiMtB patients Fith Fell%established #BS Fere recruited. he blinded comparator
Fas sham acupuncture administered bB the second of tFo acupuncturists Fho alone Fas aFare of
the randomi"ation, and Fho otherFise folloFed the prescription of the first. he primarB end%point
Fas a defined fall in the sBmptom score at D5 FG =bB intention to treat>. he prior eMpectation Fas a
5CN placebo response, and a response rate of ICN from acupuncture, for Fhich the studB Fas
ade/uatelB poFered. R8S'LS3 Patients in treated and sham groups impro(ed significantlB during
the studB%mean impro(ement in scores being e/ual =minus D.J> and significant for both =PRC.C92
one%tailed t test>. here Fas a small numeric but non%significant difference betFeen the response
rate in patients recei(ing acupuncture =6C.IN> and sham treatment =5D.?N>. Se(eral secondarB end%
points marginallB fa(ored acti(e treatment, but an impro(ed sBmptom score of anB degree of
magnitude occurred more often Fith sham therapB =;9.;N (s 9J.?N>. For no criterion Fas
statistical significance approached. !OK!L'S#OK3 raditional !hinese acupuncture is relati(elB
ineffecti(e in #BS in the 8uropean hospital setting, and the magnitude of anB effect appears
insufficient to Farrant in(estment in acupuncture ser(ices.