Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
By
H. Khorrami PhD.
http://khorrami1962.spaces.live.com
khorrami4@yahoo.com
http://www.scribd.com/khorrami4
REPRODUCTIVE ENDOCRINOLOGY
Ò Chromosome & genetic determinants, related abnormalities & syndromes.
Ò Enzymes that influence steroidogenesis.
Ò Brain, male type & female-type brain. sex and gender
Ò Puberty; theories & mechanisms involved
Ò Male reproductive organ, testis, spermatogenesis
Ò Female reproductive organ.
Ò Menstrual cycle; Ovulation, premenstrual syndrome ,follicle, hirsutism
Ò Fertilization; theories, decapacitation and capacitation.
Ò Placenta; hormonal action
Ò Physiologic changes during pregnancy
Ò Physiologic changes during pregnancy, endocrine disorders during pregnancy
Ò Parturition; pain, endocrinology of parturition
Ò Lactation; physiological functions of prolactin
Ò Menopause/ andropause
Ò Steroid hormones
Ò Growth factors
Ò Physiological actions of prostaglandins, pathological & their therapeutically usage
Ò Stem cell, cloning & related articles
SEXUAL REPRODUCTION
Ò Genetic
Ò Puberty
CHROMOSOMAL FAULTS
Ò XX karyotype
TESTICULAR FEMINIZATION
Ò X-linked recessive
Ò End pouch vagina
Ò Testes
Ò No internal female organ
Ò Breast development
Ò Paucity of pubic hair
ABNORMAL DEVELOPMENT OF REPRODUCTIVE SYSTEM
PATHWAYS OF STEROID HORMONE BIOSYNTHESIS
ESTRONE
Estradiol
ADRENAL/GONADAL ANDROGENS
STEROID ACTIVITY
STEROIDOGENESIS IN ADRENAL
DHT androstenediol
5-αreductase
ANDROGEN PRODUCTION
É Scrotum
É Penis
É Liver
Ò Hi MSH
BARON-COHEN THEORY
Ò Based on brain potential
É Empathy
É Systemize
Ò From Simon Baron-Cohen
58
SYSTEMIZING
Ò Analyze
Ò Understand
Ò Predict
Ò Control
Ò Identify
another person’s emotions & thoughts
Ò Respond with an appropriate emotion
AUTISM
Ò Androgens
Ò ….
MECHANISMS IN BRAIN DIFFERENTIATION
Ò Proliferation
Ò Uses logic detail oriented Ò Uses feeling "big picture“
facts rule oriented imagination rules
Ò Academic Ò Artistic & creative
Ò words and language Ò Symbols and images
Ò Present and future
Ò present and past
Ò Philosophy & religion
Ò math and science
Ò Meaning, believes, appreciates
Ò knows object name
Ò Spatial perception
Ò Knows object function
HEMISPHERES
ALPHA-FETO-PROTEIN
Ò Isa globulin
Ò Produced by
É Fetal liver
É Yalk sac
Ò Timing
Ò AFP
Ò SHBG
BRAIN DIFFERENCES
BRAIN TYPES
Ò Maletype brain
Ò Homosexuality
É Fraternal birth order effect
Ð Blanchard and Bogaert(1996):
Ò Pregnancy
Ò Stress
PROGESTERONE & NEUROSTEROIDS
1 Schematic of metabolic pathways in an ER-positive cell that can be affected by AIs. The left side represents the active
pathways and cellular responses under normal estrogen control. The right side depicts the blockade of pathways involving
ERs and the resultant cellular responses. AI, aromatase inhibitor; E2, estradiol; ER, estrogen receptor; MAP, mitogen-
activated protein; PI-3, phosphoinositide-3; RTK, receptor tyrosine kinase; SERD, selective estrogen receptor down-
regulator; SERM, selective estrogen receptor modulator
THESE FACTORS ARE ESSENTIAL FOR:
Ò Factorsaffecting
Ò Mechanisms involved
Ò Stages
FACTORS AFFECTING PUBERTY
Ò Genetic
Ò Geographic
Ò Socioeconomic
Ò Inheritance
Ò Altitude
Ò Lifestyle(activity)
Ò Nutrition
GONADOTROPIN SECRETION PATTERN
Ò Tonic
Ò Cyclic
CONTROL OF HT ON GONADOTROPIN SECRETION
Ò Enkephalin
Ò Progesterone
Ò Melatonin
PUBERTY GENE
Ò Gonadarche
É SHBG decrease more in boys
SHBG
Ò Peripuberty
Ò Ghrelin
Ò Leptin
Ò Orexin
Ò Amylin
Ò Obestatin
É Obestatin/Ghrelin ratio is important in obesity, IBS
& DM type II
LEPTIN
Ò SCN of HT
Ò PVN
Ò Block
out the blue rays of light to avoid
postpartum depression