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1) [10 pts] You have an idea for a molecule that disrupts the formation of the HIV capsid. Describe the
experiments/activities you would undertake to assess each of the following with 2 sentences of
detail.
a. Biological Plausibility
b. Technical Feasibility
d. Patient Outcomes
e. Societal Outcomes
2) [10 pts] For your HIV drug idea, Name one key player or stakeholder in each phase. Describe one
way they could negatively influence your assessment.
a. Biological Plausibility
b. Technical Feasibility
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Name _____________________________ ChE 395- Biotechnology and Global Health
d. Patient Outcomes
e. Societal Outcomes
3) You are evaluating tests for Hepatitis B. The following is data from a clinical trial for Test A.
a. [3 pts] What is the sensitivity for Test A?
Test A + Test A -
Hep B + 57 3
Hep B - 43 97
b. [3 pts] What is the positive predictive value for Test
A?
Test A will be used as a screen that will be carried out in a local clinic, and another test (Test B) will
be used to confirm infection at a hospital.
c. [3 pts] For Test A, is sensitivity or positive predictive value more important? Why?
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Name _____________________________ ChE 395- Biotechnology and Global Health
(Problem 3 cont’d)
d. [3 pts] For Test B, is sensitivity or positive predictive value more important? Why?
I
IV
II V
III
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Name _____________________________ ChE 395- Biotechnology and Global Health
5) [6 pts] Different TB diagnostic tests may give false positive or false negative results for active TB. For
each of these tests, predict the test result (positive/negative) and why you would expect that result.
a. Skin test on latent TB infection
6) [5 pts] Are the following groups susceptible to Toxoplasmosis because of a weak immune system
(yes/no)?
a. ____ Infants
b. ____ Adults
c. ____ Elderly
d. ____ Early stage HIV
e. ____ Late stage HIV
7) [6 pts] Select 3 of the following 4 categories: biosensors, biomaterials, tissue engineering, systems
biology. For each category, describe a healthcare technology application in one sentence.
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Name _____________________________ ChE 395- Biotechnology and Global Health
8) [9 pts] Oral Rehydration Therapy (ORT) is used to treat cholera by preventing water loss due to
diarrhea. Answer the following questions in words or with drawings.
a. What is the driving force for water to be absorbed in the gut?
10) [4 pts] Describe how a lateral flow device (e.g., pregnancy test) works. Use words or drawings.
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Name _____________________________ ChE 395- Biotechnology and Global Health
11) [6 pts] For each of the following, write (i) one possible origin of that type of stem cell, and (ii) if it can
differentiate to any cell, or just a subset. (Circle ‘Any cell’ or ‘Subset of cells’. You do not need to
identify which type it would differentiate).
a. Embryonic stem cell
i. Origin
ii. Differentiation - Any cell | Subset of cells
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Name _____________________________ ChE 395- Biotechnology and Global Health
____The immune system clears many cancers that are never detected.
Q Points Score
1 10
2 10
3 12
4 5
5 6
6 5
7 6
8 9
9 4
10 4
11 6
12 7
13 16
100
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