Summary of the January 6, 2015 issue, including articles on cytomegalovirus, Ebola, lupus nephritis, d-dimer testing to guide anticoagulation cessation after VTE, thyroid dysfunction, and knee osteoarthritis, as well as the TRIPOD (Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis) statement and commentaries on FDA's proposed cigarette labeling regulation and Ebola. Also introducing "From the Annals Archives," a special feature to celebrate the American College of Physicians' centennial.