Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets
()
About this ebook
Coronaviruses (CoVs) may lead to lethal infections, but currently no effective antiviral therapeutics or vaccines are available. The pandemic of the deadly COVID-19 is a reminder that such coronaviruses can emerge at any time. Novel human coronaviruses (HCoVs) may lead to Acute Respiratory Distress Syndrome (ARDS) and renal failure. They are highly transmissible and can spread from person-to-person through close contact. Broad-spectrum antiviral drugs may lower the vulnerability of public health systems to the coronavirus pandemic. Experiences from SARS and MERS outbreaks have revealed the demands for drugs with pan-coronavirus antiviral activities. The potential antiviral agents include neutralizing antibodies and drugs targeting the coronaviral envelope protein. Vaccine platforms can be used to transport antigens and immunostimulatory cytokines to enable protective immunity. Some compounds have been found to inhibit the replication of SARS and Ebola viruses. These compounds may be useful for the development of broad-spectrum drugs against viruses. Medicinal herbs and extracts have potential anti-CoV effects. The herbal extracts may inhibit viral replication and suppress SARS-CoV protease activity. The antiviral effects of regular household products have been evaluated against SARS-CoV. Studies of SARS-CoV have focused on the accessory proteins, host cell entry, nucleocapsid protein, spike protein, and viral proteases. The SARS-CoV and MERS-CoV have altered signaling pathways for evading early innate immune responses. Understanding of these mechanisms is critical for finding drugs for the treatment of COVID-19, SARS, MERS, and other coronavirus diseases.
Related to Potential Antiviral Agents for Coronaviruses
Related ebooks
Herbal medicine: Herbal Antibiotics ,The Ultimate Guide Guide to Healing Common Ailments Rating: 0 out of 5 stars0 ratingsA POTENTIAL TREATMENT FOR CORONAVIRUS DISEASE (COVID-19): ANTIVIRAL EFFECT OF MEDICINAL PLANT EXTRACTS Rating: 0 out of 5 stars0 ratingsHerbal Antivirals Book: The Ultimate Guide to Herbal Healing, Magic, Medicine, Antivirals, and Antibiotics Rating: 0 out of 5 stars0 ratingsCovid-19 Remedies: A Frontline Doctor's View Rating: 0 out of 5 stars0 ratingsCancer Therapy Rating: 0 out of 5 stars0 ratingsCovid-19: 19+ Comforts From The Bible Rating: 0 out of 5 stars0 ratingsMedicinal Herbs To Boosts Immune System Plus Prevent Disease Bilingual Edition English Germany Rating: 0 out of 5 stars0 ratingsNanotechnology-Based Targeted Drug Delivery Systems for Lung Cancer Rating: 0 out of 5 stars0 ratingsCancer Preventive and Therapeutic Compounds: Gift From Mother Nature Rating: 0 out of 5 stars0 ratingsVascular Health Rating: 0 out of 5 stars0 ratingsChemistry and Bioactivity of Boswellic Acids and Other Terpenoids of the Genus Boswellia Rating: 0 out of 5 stars0 ratingsSaffron: The Age-Old Panacea in a New Light Rating: 0 out of 5 stars0 ratingsModern Applications of Plant Biotechnology in Pharmaceutical Sciences Rating: 0 out of 5 stars0 ratingsNanotheranostics for Treatment and Diagnosis of Infectious Diseases Rating: 5 out of 5 stars5/5MCT Oil Smoothies Recipe Book: A Beginners Guide to MCT Oil Smoothies for Weight Loss Rating: 0 out of 5 stars0 ratingsOne Way Trip Rating: 5 out of 5 stars5/5Herbal Supplements: Efficacy, Toxicity, Interactions with Western Drugs, and Effects on Clinical Laboratory Tests Rating: 0 out of 5 stars0 ratingsHS Journal, Vol. I, Issue 9 Rating: 0 out of 5 stars0 ratingsFibromyalgia: The Natural Approach to Pain-Free Living Rating: 0 out of 5 stars0 ratingsVirus Alert: Security, Governmentality, and the AIDS Pandemic Rating: 0 out of 5 stars0 ratingsMeyler's Side Effects of Antimicrobial Drugs Rating: 5 out of 5 stars5/5Magic of Black Seeds: Useful kitchen Items for your health, #1 Rating: 0 out of 5 stars0 ratingsRole of Nutraceuticals in Cancer Chemosensitization Rating: 4 out of 5 stars4/5How to Save Your Loved Ones From COVID Rating: 0 out of 5 stars0 ratingsIndividualized Drug Therapy for Patients: Basic Foundations, Relevant Software and Clinical Applications Rating: 0 out of 5 stars0 ratingsHerbal Antibiotics: Over 33 Foods & Herbs with Natural Antibiotic Properties To Help You Get Rid of Your Pills Rating: 0 out of 5 stars0 ratingsAntiprotozoal Drug Discovery: A Challenge That Remains Rating: 0 out of 5 stars0 ratingsSeven Plant Medicines to Build Superior Immunity & Protect You from Viral Attack! Rating: 0 out of 5 stars0 ratingsThe Foolproof Cure for Cancer Rating: 5 out of 5 stars5/5
Wellness For You
The Diabetes Code: Prevent and Reverse Type 2 Diabetes Naturally Rating: 4 out of 5 stars4/5The Subtle Art of Not Giving a F*ck: A Counterintuitive Approach to Living a Good Life Rating: 4 out of 5 stars4/5Sex Hacks: Over 100 Tricks, Shortcuts, and Secrets to Set Your Sex Life on Fire Rating: 4 out of 5 stars4/5The Big Book of 30-Day Challenges: 60 Habit-Forming Programs to Live an Infinitely Better Life Rating: 4 out of 5 stars4/5The Healing Remedies Sourcebook: Over 1,000 Natural Remedies to Prevent and Cure Common Ailments Rating: 0 out of 5 stars0 ratingsBigger Leaner Stronger: The Simple Science of Building the Ultimate Male Body Rating: 5 out of 5 stars5/5Thinner Leaner Stronger: The Simple Science of Building the Ultimate Female Body Rating: 4 out of 5 stars4/5Summary of Lindsay C. Gibson's Adult Children of Emotionally Immature Parents Rating: 5 out of 5 stars5/5Why We Sleep: Unlocking the Power of Sleep and Dreams Rating: 4 out of 5 stars4/5Mating in Captivity: Unlocking Erotic Intelligence Rating: 4 out of 5 stars4/5The Illustrated Easy Way to Stop Drinking: Free At Last! Rating: 4 out of 5 stars4/5How Not to Diet: The Groundbreaking Science of Healthy, Permanent Weight Loss Rating: 4 out of 5 stars4/5Summary of Anna Lembke's Dopamine Nation Rating: 4 out of 5 stars4/5Feeling Good: The New Mood Therapy Rating: 4 out of 5 stars4/5How Am I Doing?: 40 Conversations to Have with Yourself Rating: 5 out of 5 stars5/5Deep Nutrition: Why Your Genes Need Traditional Food Rating: 4 out of 5 stars4/5The Little Book of Hygge: Danish Secrets to Happy Living Rating: 4 out of 5 stars4/5When the Body Says No Rating: 5 out of 5 stars5/5Glucose Revolution: The Life-Changing Power of Balancing Your Blood Sugar Rating: 5 out of 5 stars5/5The Blue Zones, Second Edition: 9 Lessons for Living Longer From the People Who've Lived the Longest Rating: 4 out of 5 stars4/5The Happiness Makeover: Overcome Stress and Negativity to Become a Hopeful, Happy Person Rating: 4 out of 5 stars4/5
Reviews for Potential Antiviral Agents for Coronaviruses
0 ratings0 reviews
Book preview
Potential Antiviral Agents for Coronaviruses - Dr. Pharm Tao
Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets
Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets
Pharm Tao
2020
ISBN 9781005839895
Copyright © 2020 by Pharm Tao
All rights reserved. No parts of this publication may be reproduced or utilized, stored in a retrieval system, or transmitted, in any form or by any means, electronic or mechanical, including photocopying, recording, or otherwise, without prior written permission from the copyright owner.
The information in this publication is true and complete to the best of our knowledge. The author disclaims any liability in connection with the use of this information. The information provided is not intended for diagnosis, or to treat, cure or prevent any diseases, conditions or symptoms, or to endorse any products. Personal directions and use of drugs and herbs should be provided by qualified health professionals.
Publisher’s Website: www.pharmtao.com
Contents
Preface 5
Chapter 1: Potential Broad-Spectrum Antiviral Drugs 6
Chapter 2: Potential Antiviral Compounds 13
Chapter 3: Antiviral Herbal Extracts for Coronaviruses 17
Chapter 4: Potential Antivirals for SARS-CoV 29
Chapter 5: Drug Targets for Coronaviruses 38
Preface
Coronaviruses (CoVs) may lead to lethal infections, but currently no effective antiviral therapeutics or vaccines are available.
The pandemic of the deadly COVID-19 is a reminder that such coronaviruses can emerge at any time.
Novel human coronaviruses (HCoVs) may lead to Acute Respiratory Distress Syndrome (ARDS) and renal failure.
They are highly transmissible and can spread from person-to-person through close contact.
Broad-spectrum antiviral drugs may lower the vulnerability of public health systems to the coronavirus pandemic.
Experiences from SARS and MERS outbreaks have revealed the demands for drugs with pan-coronavirus antiviral activities.
The potential antiviral agents include neutralizing antibodies and drugs targeting the coronaviral envelope protein.
Vaccine platforms can be used to transport antigens and immunostimulatory cytokines to enable protective immunity.
Some compounds have been found to inhibit the replication of SARS and Ebola viruses.
These compounds may be useful for the development of broad-spectrum drugs against viruses.
Medicinal herbs and extracts have potential anti-CoV effects.
The herbal extracts may inhibit viral replication and suppress SARS-CoV protease activity.
The antiviral effects of regular household products have been evaluated against SARS-CoV.
Studies of SARS-CoV have focused on the accessory proteins, host cell entry, nucleocapsid protein, spike protein, and viral proteases.
The SARS-CoV and MERS-CoV have altered signaling pathways for evading early innate immune responses.
Understanding of these mechanisms is critical for finding drugs for COVID-19, SARS, MERS, and other coronavirus diseases.
Chapter 1: Potential Broad-Spectrum Antiviral Drugs
Coronaviruses (CoVs)
Coronaviruses (CoVs) may lead to lethal infections, but currently no effective antiviral therapeutics or vaccines are available.
The pandemic of the deadly coronavirus