Summary of the September 3, 2013 issue, including articles on the carpal tunnel syndrome, social media use and HIV education, and pathologic evaluation of thyroid nodules, as well as the USPSTF recommendation on screening for peripheral artery disease and cardiovascular disease risk assessment with the ankle-brachial index and its background review, the USPSTF recommendation on screening for hepatitis C virus, and commentaries on lung transplantation and the new DSM-5.