Summary of the April 21, 2015 issue, including articles on statins in older adults, metformin and prediabetes, appropriate use criteria for coronary angiography, EHR-based interventions for appropriate diagnostic imaging, and screening for iron deficiency anemia in pregnancy, as well as the first of a new series, "Beyond the Guidelines: Grand Rounds Discussions From the Beth Israel Deaconess Medical Center" (this issue's topic is lung cancer screening), an ACP position paper on electronic nicotine delivery systems, and commentaries on the ACP centennial and on the "virtual" house call.