Acromegaly, A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions
By Kenneth Kee
()
About this ebook
Acromegaly is a rare disease which is caused when the pituitary gland produces too much growth hormone.
Normally a benign (non cancerous) tumor of the pituitary gland results in the gland producing too much growth hormone.
Too much growth hormone in children produces gigantism rather than acromegaly.
Symptoms of acromegaly are:
1. Reduced muscle strength (weakness)
2. Reduced peripheral vision
3. Easy fatigue
4. Increased height
5. Large bones of the face
6. Large feet (change in shoe size), large hands (change in ring or glove size)
7. Large glands in the skin (sebaceous glands)
8. Large jaw (prognathism) and tongue (macroglossia)
There are other symptoms that may occur with this condition:
1. Colon polyps
2. Increased hair growth in females (hirsutism)
3. Type 2 diabetes
4. Enlarged thyroid
To confirm diagnosis of acromegaly the following tests may be done:
1. Growth hormone
2. Blood glucose
3. High insulin-like growth factor 1 (IGF-1) level
4. Spine x-ray
5. MRI of the brain, including the pituitary gland
Treatment
1. Surgery for removal of the pituitary tumor that is causing this condition often treats the release of abnormal growth hormone.
Sometimes the tumor is too big to remove totally.
2. People who are not responsive to surgery may have radiation of the pituitary gland.
3. Tests of pegvisomant (Somavert), a GH-receptor antagonist, showed effective suppression of GH and IGF-I levels in patients with acromegaly due to pituitary tumors or ectopic GHRH hypersecretion.
Normalization of IGF-I levels occurs in as many as 90% of patients treated daily with this drug for 3 months.
4. Bromocriptine (Parlodel, Cycloset)
This is the dopamine-receptor agonist that is most often used to treat GH and prolactin excess.
It is safe when administered to a child for extended period.
In acromegaly, a severe disease that is often diagnosed late, morbidity and mortality rates are high, particularly as a result of associated cardiovascular, cerebrovascular, and respiratory disorders and malignancies.
Because IGF-I is a general growth factor, somatic hypertrophy in acromegaly occurs across all organ systems.
Associated complications include the following:
1. Acromegalic heart
2. Increased muscle and soft tissue mass
3. Increased kidney size
4. Articular overgrowth of synovial tissue and hypertrophic arthropathy
5. Joint symptoms, back pain, and kyphosis
TABLE OF CONTENT
Introduction
Chapter 1 Acromegaly
Chapter 2 Causes
Chapter 3 Symptoms
Chapter 4 Diagnosis
Chapter 5 Treatment
Chapter 6 Prognosis
Chapter 7 Dwarfism or Growth Hormone Deficiency
Epilogue
Kenneth Kee
Medical doctor since 1972.Started Kee Clinic in 1974 at 15 Holland Dr #03-102, relocated to 36 Holland Dr #01-10 in 2009.Did my M.Sc (Health Management ) in 1991 and Ph.D (Healthcare Administration) in 1993.Dr Kenneth Kee is still working as a family doctor at the age of 74However he has reduced his consultation hours to 3 hours in the morning and 2 hours inthe afternoon.He first started writing free blogs on medical disorders seen in the clinic in 2007 on http://kennethkee.blogspot.com.His purpose in writing these simple guides was for the health education of his patients which is also his dissertation for his Ph.D (Healthcare Administration). He then wrote an autobiography account of his journey as a medical student to family doctor on his other blog http://afamilydoctorstale.blogspot.comThis autobiography account “A Family Doctor’s Tale” was combined with his early “A Simple Guide to Medical Disorders” into a new Wordpress Blog “A Family Doctor’s Tale” on http://ken-med.com.From which many free articles from the blog was taken and put together into 1000 eBooks.He apologized for typos and spelling mistakes in his earlier books.He will endeavor to improve the writing in futures.Some people have complained that the simple guides are too simple.For their information they are made simple in order to educate the patients.The later books go into more details of medical disorders.He has published 1000 eBooks on various subjects on health, 1 autobiography of his medical journey, another on the autobiography of a Cancer survivor, 2 children stories and one how to study for his nephew and grand-daughter.The purpose of these simple guides is to educate patient on health disorders and not meant as textbooks.He does not do any night duty since 2000 ever since Dr Tan had his second stroke.His clinic is now relocated to the Buona Vista Community Centre.The 2 units of his original clinic are being demolished to make way for a new Shopping Mall.He is now doing some blogging and internet surfing (bulletin boards since the 1980's) startingwith the Apple computer and going to PC.The entire PC is upgraded by himself from XT to the present Pentium duo core.The present Intel i7 CPU is out of reach at the moment because the CPU is still expensive.He is also into DIY changing his own toilet cistern and other electric appliance.His hunger for knowledge has not abated and he is a lifelong learner.The children have all grown up and there are 2 grandchildren who are even more technically advanced than the grandfather where mobile phones are concerned.This book is taken from some of the many articles in his blog (now with 740 posts) A Family Doctor’s Tale.Dr Kee is the author of:"A Family Doctor's Tale""Life Lessons Learned From The Study And Practice Of Medicine""Case Notes From A Family Doctor"
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Acromegaly, A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions - Kenneth Kee
Acromegaly,
A
Simple
Guide
To
The Condition,
Diagnosis,
Treatment
And
Related Conditions
By
Dr Kenneth Kee
M.B.,B.S. (Singapore)
Ph.D (Healthcare Administration)
Copyright Kenneth Kee 2015 Smashwords Edition
Published by Kenneth Kee at Smashwords.com
Dedication
This book is dedicated
To my wife Dorothy
And my children
Carolyn, Grace
And Kelvin
This book describes the Acromegaly, Diagnosis, Treatment and Associated Diseases or in vernacular terms
(What You Need to Treat and Cope with Acromegaly)
This eBook is licensed for the personal enjoyment only. This eBook may not be re-sold or given away to other people. If you would like to share this book with another person, please purchase an additional copy for each reader.
If you’re reading this book and did not purchase it, or it was not purchased for your use only, then please return to Smashwords.com and purchase your own copy.
Thank you for respecting the hard work of this author.
Introduction
I have been writing medical articles for my blog http://kennethkee.blogspot.com (A Simple Guide to Medical Condition) for the benefit of my patients since 2007.
My purpose in writing these simple guides was for the health education of my patients.
Health Education was also my dissertation for my Ph.D (Healthcare Administration).
I then wrote an autobiolographical account of his journey as a medical student to family doctor on his other blog http://afamilydoctorstale.blogspot.com.
This autobiolographical account A Family Doctor’s Tale
was combined with my early A Simple Guide to Medical Conditions
into a new Wordpress Blog A Family Doctor’s Tale
on http://ken-med.com.
From which many free articles from the blog was taken and put together into 590 amazon kindle books and some into Smashwords.com eBooks.
Some people have complained that the simple guides are too simple.
For their information they are made simple in order to educate the patients.
The later books go into more details of medical conditions.
The first chapter is always from my earlier blogs which unfortunately tends to have typos and spelling mistakes.
Since 2013, I have tried to improve my spelling and writing.
As I tried to bring you the latest information about a condition or illness by reading the latest journals both online and offline, I find that I am learning more and improving on my own medical knowledge in diagnosis and treatment for my patients.
Just by writing all these simple guides I find that I have learned a lot from your reviews (good or bad), criticism and advice.
I am sorry for the repetitions in these simple guides as the second chapters onwards have new information as compared to my first chapter taken from my blog.
I also find repetition definitely help me and maybe some readers to remember the facts in the books more easily. I apologize if these repetitions are irritating to some readers.
Chapter 1
Acromegaly
What is Acromegaly?
Acromegaly is a rare disease of the pituitary gland which produces excessive growth hormone in the body.
What are the Causes of Acromegaly?
Acromegaly is a rare disease which is caused when the pituitary gland produces too much growth hormone.
A small pea-sized endocrine gland the pituitary gland is located at the base of the brain.
It controls, produces, and releases several hormones including growth hormone.
Normally a benign (non cancerous) tumor of the pituitary gland results in the gland producing too much growth hormone.
Too much growth hormone in