The 85% Solution
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New Edtition!
MTHFR is Overpowering Our Medical System -- Chances Are You Have It Too…
The 85% Solution The newest book from best-selling (10 #1 books on Amazon) author Dan Purser MD. Learn how most of the US population carries the gene for this mysterious disorder – MTHFR -- and up to 15% actually have the disease – they have methylation problems, folate deficiency, and lack of methylfolate in their diet and it’s killing them, and possibly you. (Folic acid is toxic to you and the right folate, the safe folate -- natural methylfolate -- is necessary.) Learn about the meaning of MTHFR Heterozygous, C677T, MTHFR Homozygous, A1298C, folate depression, as you find out how to use a MTHFR Protocol for each disease, use natural folate, methylfolate dosage, MTHFR vitamins, and how to diagnose or figure out if you have MTHFR disease, giving you AMAZING relief in this UNIQUE MTHFR Book by famous medical author, Dan Purser MD. Have you had problems with depression but most anti-depressants made it worse? Birth control pill problem or they’ve FLIPPED you or a loved one completely out and were quickly stopped? Are you fatigued all the time but despise stimulants and amphetamines which doctors seem to readily prescribe? Regular vitamins give you a gut ache and nausea and make you feel worse? Do you need to drink energy drinks just to stay awake? And you’re only 23? Why?
Get this thorough book which covers all of the following: Subjects discussed on this book are MTHFR, mthfr mutation, mthfr gene, mthfr treatment, mthfr gene mutation, mthfr deficiency, mthfr a1298c, right folate, safe folate, folate gene, folate depression. mthfr and folic acid, mthfr test, mthfr c677t, mthfr and cancer, mthfr support, mthfr diet, mthfr depression, mthfr and miscarriage, mthfr autism, mthfr and vaccines, mthfr mutation c677t, mthfr and depression, mthfr a1298c homozygous, mthfr and thyroid, mthfr and anesthesia, mthfr and birth control, mthfr a1298c mutation, mthfr and b12, mthfr and homocysteine, mthfr adhd, mthfr and migraines, mthfr alcohol, mthfr and histamine, mthfr and diabetes, genetic illness, mthfr diet, mthfr c677t, mthfr a1298c, mthfr deficiency, mthfr depression, mthfr mutation c677t, mthfr diet, mthfr and thyroid, methylfolate supplement, methylfolate dosage, methylfolate, methylfolate trap, birth control pill problems, folate deficiency, folate gene mutation, folate depression, folate disease, mthfr protocol, mthfr book, mthfr vitamins, mthfr disease, mthfr heterozygous, mthfr homozygous, mthfr, C677T, A1298C, methylfolate, natural folate, methylation, methylation disease, and COMT. Also, treatment protocols are discussed and new and cheaper and easier way to make the correct diagnosis are detailed and explained – many lab examples are also given. Get it now – today! And start feeling the clarity, and energy for the first time in your life! Other websites to which you can refer: http://ghr.nlm.nih.gov/gene/MTHFR http://mthfr.net/ https://en.wikipedia.org/wiki/Methylenetetrahydrofolate_reductase http://www.stopthethyroidmadness.com/mthfr/
Dan Purser MD
Dr. Dan Purser (www.danpursermd.com), graduated with Honors from Brigham Young University and the University of Mississippi School of Medicine, and after years of endocrinology research is the bestselling author of 10 books, including co-writing a textbook, Program120: A Physician's Guide to Proactive Preventive Medicine, and the Program 120 Handbooks. His men's health book, Improving Male Sexuality, Fertility and Testosterone, was #1 in the Amazon Health Sex section for more than a week and his breast cancer book, The Breast Cancer Patient's Survival Guide: Amazing Strategies for Winning, was #1 in the Amazon Health Reference section. He is also an entertaining and dynamic educator and speaker (he has never NOT been voted as The Most Popular Speaker at any conference at which he's spoken) and is popular among both the public and physicians, and has travelled many thousands of miles doing book, radio and product tours all over the world. He is also the founder of a couple of successful health product design companies through which he makes a number of products for nutraceutical companies. He is also a BIG fan of Disneyland and Disney World where you can probably find him in his off time with his wife and some of their 10 children.
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The 85% Solution - Dan Purser MD
1––––––––ROOT CAUSES OF THE MTHFR MUTATION
THE CURRENT HUMAN race lives and procreates a long time.
I had just had a daughter and was turning 50.
Wow, was I crazy or what?
It wasn’t that long ago that the average American lived to be in their late 20’s (three generations back), women were getting married in their teens and having babies, then dying in child birth. Only one out of ten children lived to adulthood – much lower in other countries. Now we’re living into our 90’s regularly. With our longer life expectancy, we are passing on more gene defects. There’s no doubt. It’s just the way it is.
MTHFR (ACTUALLY called MethyleneTetraHydroFolate Reductase Enzyme Deficiency) came along in northern Europe several hundred generations ago and now has blown up (85% of the population carries a variant or at least a SNP of this gene mutation[1] [stands for Single Nucleotide Polymorphism] or more appropriately called a transcription error, 5% carries both genes so are homozygous). And oddly enough 49% of the Latino or Hispanic population are carriers or have the MTHFR disease. Well, I guess it’s not really a disease or mutation – it’s actually just a DNA replication or copying problem called a TRANSCRIPTION ERROR. Wow, what an error.
Methylation is probably THE most important enzyme function our body makes – it controls so much – and is deeply and inherently tied to our energy levels, both perceived and actual.
You always have to wonder how mutations survive – especially cruddy ones like this one – studies have shown that it’s a survival gene mutation against colon cancer[2] (crazy right? But I knew it had to give some type of x-man powers).
And why does your doctor not know about this or recognize it? I’m not sure. I think my brothers and sisters in the medical field are just too busy with getting patients out of the office – they are overwhelmed, seeing 60 patients a day (I never see more than 8).
This book, always a work in motion, makes an attempt at detailing the diagnosis, diseases, and treatments of this disease more thoroughly to make it all more comprehensible for you and me.
2––––––––HERE’S WHAT A
HEALTHY MTHFR GENE DOES FOR YOU
The breath-taking in scope Human Genome Project was completed in April of 2003. The Project’s goal was to provide researchers with powerful tools to understand the genetic factors in human disease, paving the way for new strategies for their diagnosis, treatment and prevention[3] - this fueled the discovery of more than 1,800 disease genes including MTHFR problems (transcription errors). When it’s all working right, the MTHFR genes, on Chromosome 1, begin a multi-step chemical methylation process, which goes like this:
The MTHFR gene leads to production of the MTHFR enzyme.
The MTHFR enzyme works with the folate vitamins (B9, folic acid), breaking it down from 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate
5-methyltetrahydrofolate helps convert the amino acid homocysteine down to another essential amino acid, methionine, which is used by your body to make proteins, utilize antioxidants, and to assist your liver to process fats. Methionine helps with depression, reduces inflammation and helps convert estradiol (E2) into estriol (E3) (i.e. critical to hormone production – where I tend to come in).
Methionine is converted in your liver into SAM-e (s-adenosylmethionine), which is anti-inflammatory, supports your immune system, helps produce critical brain chemicals such as serotonin, dopamine and melatonin, and is involved in the growth, repair and maintenance of your cells. (Why these patients deal with a lot of depression and no, SSRIs don’t always work with them.)
You’ll also make glutathione through this proper methylation pathway. For example, if you create more glutathione it means you will have a better chance in eliminating toxins and heavy metals, which can reduce your risk for cancer, other health issues, and put less stress on your adrenals.
And from the National Library of Medicine we learn[4]:
The official name of this gene is
methylenetetrahydrofolate reductase (NAD(P)H)."
MTHFR is the gene's official symbol.
SAMe, which we’ll discuss later, is made of methionine. And with the MTHFR enzyme deficiency (which is what we’re talking about here) you may not be able to make methionine or SAMe, so you may be suffering from a SAMe deficiency also. But there’s a way to cut through what used to be a lot of testing – and I’ll show you how.
Read on.
3––––––––WHAT A DEFECTIVE (MUTATED) MTHFR GENE DOES TO YOU
(Some of this was borrowed from this
EXCELLENT website – please go there - http://www.stopthethyroidmadness.com/mthfr/)
WHAT DOES A defective MTHFR gene structure do to you?[5]
It causes a reduction in the production of the critical MTHFR enzyme, causing methylation to occur at only 40% of a healthy body’s capacity, or even as much as 70% of its capacity (still bad though). It can mean you could have been diagnosed with heavy metal toxicity – you won’t break down toxins or heavy metals fast enough – i.e. you could find yourself with high iron, or high copper, or high lead, or high mercury....etc. High copper can also cause low ferritin, even though your iron levels look great (take natural Vitamin C to lower copper levels in this case – but your Spectracell® Metabolic Panel will have probably have shown you have a Vitamin C deficiency at this point)!
The defective enzyme doesn’t break down folate vitamins properly (of which folic acid is the precursor to), which can cause high homocysteine levels (hyperhomocysteinuria), which causes vascular inflammation which in turn can increase your risk of coronary heart disease (arteriosclerotic vascular disease or venous thrombosis), and related heart and high BP conditions, as well as increasing your risk for dementia. (This vascular inflammation can explain why someone young has high blood pressure of unknown cause—in turn when treated, their BP should drop to normal).
Homocysteine is then inadequately converted to glutathione, which is your body’s chief antioxidant and detoxifier. You are then more susceptible to fatigue, stress and toxin buildup (see the chapter on glutathione for more info).
Homocysteine is poorly converted to methionine, and less methionine can raise your risk of arteriosclerosis, fatty liver degenerative disease, anemia, increased inflammation, increased free radical damage... and produce less SAMe.
Less SAMe can increase depression (another reason why these patients have high levels of depression – this is most appropriately treated with vitamins, not anti-depressants).
You can become toxic with high folate or high B12 levels, i.e. your body will have problems converting inactive forms of folate and B12 to the active forms. So the inactive folate or B12 will simply build up in your serum, also inhibiting the active forms. Most serum folate tests are actually measuring folic acid, which needed to be converted to methylfolate to be used metabolically.
More Than One TRANSCRIPTION ERROR of the MTHFR Gene
Genes are passed down by your mother and your father. Most literature states there are a good 40-50 different mutations of this important gene which could be passed down by one, or both of your parents. But only three are particularly problematic: transcription errors (it’s technically not a mutation but a copying or transcription error) on the points at C677T and A1298C, and to a lesser degree COMT. The 677 and 1298 numbers refer to their location on the first gene. You will also sometimes just see them written as just 677 and 1298.
There are multiple potential combinations of MTHFR:
Homozygous: means you have both copies of either the 677 error, or the 1298 error, since you’re getting one from each parent.
Heterozygous: means you have one copy of either the 677 error, or the 1298 error, plus a normal one from the other parent. For example - C677T error alone can cause a decrease of 40% in your methylation capabilities.
Compound Heterozygous: means you have one copy of the 677 error from one parent and one copy of the 1298 error from the other parent.
Triple homozygous errors (more rare): an example would be one C677T, one A1298C, and a P39P or R594Q,.
Here are the possible combinations:
Normal/Normal for both 677 and 1298
Heterozygous 1298 / Normal 677 (one parent passed down a single 1298 error)—No