This regional overview has been prepared to take stock of the current food security situation, present the challenges of ensuring food security in the context of growing and changing patterns of food demand, and propose key measures that must be taken in a coordinated manner by different stakeholders in this very dynamic and populous part of the world. Part I presents the region’s progress in meeting the Millennium Development Goal 1 and the World Food Summit targets in reducing the proportion and number of undernourished, respectively. Part II discusses insights from a suite of indicators related to the four dimensions of food security (food availability, access to food, stability and utilization); the future outlook towards 2050; policies, actions, commitments and initiatives by countries and regional organizations to address existing and emerging food security challenges; and finally, the path ahead to eradicating hunger and ensuring food and nutrition security in the region.