Gilbert's Syndrome: Causes, Tests and Treatment Options
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The liver is one of the busiest and most important organs in your body. When it functions properly, it detoxifies harmful substances and filters impurities, stores energy, processes carbohydrates, and breaks down fats. To help you digest your food, a yellowish brown fluid in the gallbladder is discharged to break down fats and lipids in the intestines. Unfortunately, a common, mild disorder may take place causing this yellowish-brown pigment in the bile to increase in high levels. This pigment—known as bilirubin—causes the skin and whites of the eyes to turn yellow or jaundiced. A person with this kind of disorder is thought to have an inherited Gilbert’s syndrome (GS). If you or a loved one is suffering from this common disorder, there are treatment options that can help. This must-have book contains information about a wide range of treatments for Gilbert's Syndrome, from dietary changes to unconventional therapies like meditation and yoga.
Michael Harper
Michael D. Harper is a native of Atlanta, Georgia, where he obtained a Bachelor’s Degree in Interdisciplinary Studies from Georgia State University, and later a Juris Doctorate degree from Boston College School of Law. Mr. Harper has been a practicing attorney in private practice for over seventeen years. His law firm is currently located in the Buckhead area of Atlanta, Georgia where he specializes in civil litigation. He has a daughter who currently resides in Atlanta, Georgia. Mr. Harper’s interests include being an enthusiast for theater, sports and international travel. Mr. Harper serves on various nonprofit advisory boards in Atlanta, GA.
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Gilbert's Syndrome - Michael Harper
The liver is one of the busiest and most important organs in your body. When it functions properly, it detoxifies harmful substances and filters impurities, stores energy, processes carbohydrates, and breaks down fats. To help you digest your food, a yellowish brown fluid in the gallbladder is discharged to break down fats and lipids in the intestines. Unfortunately, a common, mild disorder may take place causing this yellowish-brown pigment in the bile to increase in high levels. This pigment—known as bilirubin—causes the skin and whites of the eyes to turn yellow or jaundiced. A person with this kind of disorder is thought to have an inherited Gilbert’s syndrome (GS).
In many cases, Gilbert’s syndrome is so mild thus giving no obvious symptoms. Most of the cases are diagnosed by accident when blood tests are undertaken to investigate for unrelated illnesses. Despite the person’s jaundiced appearance, the liver still functions normally. Though Gilbert’s syndrome is considered harmless, it is imperative to acquire appropriate information regarding this syndrome. Proper awareness and thorough knowledge on this disorder will help you receive proper medication and avoid complications.
Here are important points that you need to know regarding Gilbert’s syndrome. These will help you lead a healthy life and uphold wellness for better living.
Overview and Causes of GS
Augustine Nicolas Gilbert, a French gastroenterologist and his colleagues, first described Gilbert’s syndrome (GS) in 1901. The disorder was first recognized as a syndrome of chronic, benign, intermittent yellowing of the skin and whites of the eyes or jaundice in the absence of other liver diseases. In addition, they also described psychological symptoms including signs of chronic fatigue syndrome which refers to painful muscles and nerve inflammation.
a. Background on bilirubin
Gilbert’s syndrome starts with an increased level of bilirubin in the bloodstreams. To fully understand this disorder, it would be very helpful to trace the means on how this pigment increases in level.
Bilirubin is considered a normal by-product of iron breakdown in the blood. It is created in the natural breakdown of red blood cells (RBCs) in the spleen. These cells contain hemoglobin which is an important protein that helps transport oxygen all over the body. After 120 days, the red blood cells break into globin, a protein, and haem, a waste material. To undergo further chemical changes, haem is transported to the liver and becomes the bilirubin in the bile while the protein is stored in the liver for future use. This will be excreted from the body.
Together with other toxins and impurities, bilirubin is treated in the body’s two-phase detoxification system. The body may detoxify toxins entirely in the first phase or prepare it for the second phase. Several major systems act on these toxins in the second phase. If you are affected with Gilbert’s syndrome, the system that is responsible for processing toxins and removing them in the body is not functioning well. This is known to take place in the glucuronidation system and enzymes in this system are called uridine diphosphate glucuronyl transferase or UGT. A specific enzyme in this family is responsible in breaking down and modifying bilirubin into a water-soluble form. Bilirubin in watery version is secreted easily into bile through your gall bladder and into your small intestine. It is further acted by bacteria into forms of pigment substances and eventually excreted from the body in your feces and urine.
In Gilbert’s syndrome, a genetic mutation takes place that triggers only 30% of the UGT enzyme to be produced and act on the toxins. There are not enough UGT enzymes to metabolize bilirubin at the normal rate. The shortage in this type of enzyme leads to an excess of bilirubin in the blood serum. With this disorder, your liver has problems with chemical conversion and abnormally high amounts of bilirubin will circulate in the bloodstream. This causes yellowing of the skin and the whites of the eyes. In some cases, the bilirubin levels typically fluctuate and only sometimes drift within the normal range.
b. Risk factors: how is GS is passed through families?
Although studies link genetic mutation with the causes of Gilbert’s syndrome,