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Husong Li, M.D., Ph.D. Assistant Professor Department of Anesthesiology University of Texas Medical Branch Galveston, Texas
ELECTROCONVULSIVE THERAPY
INTRODUCTION TO ECT
ECT
has changed substantially during the past decades. The use of general anesthesia has promoted the interest in ECT (Ottoson 1962) ECT become more complex, more precise, and safer procedure (mortality 1/1000 early to 3-4/100,000 now)
INTRODUCTION TO ECT
Generalized
seizures for 30-60 seconds in duration are required for therapeutic effects 75-90% of patients exhibit a dramatic and sustained improvement Transient neurological dysfunction does occur but permanent neuronal injury is questionable
Generalized seizure can be induced by adjusting waveform, frequency, duration of electrical stimuli. Seizure should last at least 30-60 seconds in duration Good therapeutic effect is generally not achieved until 400-700 seizure seconds Treatments are usually given every other days unto 12 sessions Treatment endpoints are based on clinical experience and evaluation
depression: if drug treatment fails or is not tolerated ( i.e. elderly with Parkinson's disease ) Bipolar disorder: manic or depressed phase Acute or Catatonic Schizophrenia Patient is severely withdrawn or starving: effects seen in days rather than weeks Depression in pregnancy: with acute mania
CONTRAINDICATIONS TO ECT
ABSOLUTE
RELATIVE
CV Recent MI < 3 months; Severe angina, CHF Aneurysm of major vessel Pheochromocytoma CNS Cerebral tumor or aneurysm Recent CVA <1 month Respiratory System Severe respiratory failure
Initial Parasympathetic Discharge (15 seconds) Bradycardia: marked Bradycardia <30 bpm or transient asystole Increased secretion Increased intragastric and intraocular pressure
Sustained Sympathetic Discharge (1-3 min) Tachycardia Hypertension Dysrhythmias and Twave abnormalities CNS: increased CBF, ICP, O2 consumption
contractions: can result in fractures and dislocations; prevented by small doses of muscle relaxants Injury to teeth, tongue or lips: stimulus causes intense contraction of the masseter muscles and forceful movement of the jaw; use a bite block Electrical injury to the staff or patient
ache Short-term memory loss and cognitive deficits Difficult relationship with patients: frightened; withdrawn; suspicious; uncooperative Anesthesia related problem: i.e. air way issue (more pt with OSA); aspiration Line infection and sepsis
TREATMENT PROTOCOL
Premedicate Glycopyrrolate and Beta blocker ? Patient not intubated Bite block Cuff leg to monitor seizure activity EEG and EMG Length of seizure: 30 sec to 1 min.
ECT DEVICE
EEG ACTIVITY
PRE-ECT EVALUATION
Regular
anesthesia pre-op evaluation: Esp. airway, CV, CNS Psychotropic medication should be stopped before ECT (antidepressants, benzodiazepine, lithium) for 7 days? Pre-ECT sedation: hydroxyzine or promethazine 25-50 mg, droperidol 2.5-5 mg (promote seizure) Pain medication prior to ECT
INDUCTION AGENTS
An ideal agent: rapid unconsciousness, painless on injection, no hemodynamic effects, no anticonvulsant properties, rapid recovery, and inexpensive (APA1990,
2001; Folk et al, 2000) Brevital Sodium : 0.5-1 mg/kg thiopental: 2-4 mg/kg ketamine: 0.5-2 mg/kg propofol: 1.5-3 mg/kg etomidate: 0.15-0.3 mg/kg
MUSCLE RELAXANTS
Succinylcholine:
0.3-1.5 mg/kg. Atracurium, 0.3-0.5 mg/kg (Hickey et al, 1987) Mivacurium, 0.15-0.2 mg/kg (Kelly & Brull, 1994) Rocuronium, 0.45-0.6 mg/kg (Motamed et al, 1997)
ADJUNCTIVE AGENTS
Caffeine 0.25-1.5 gm IV Flumazenil: 0.2-1 mg IV (benzodiazepine antagonist) Benzodiazepine: Valium 5-10 mg IV (status epilepticus) Anticholinergics: atropine 0.4-0.8 mg IV or glycopyrrolate 0.2-0.4 mg IV Beta blockers: Labetalol and Esmolol Nitroglycerine Antihypertensives: Labetalol, Trimethaphan, Nicardipine
POST-ECT RECOVERY
Headache:
N/V:
Up to 45 % (Devanand
(Gomez 1975;
1.4% - 23%
Muscle
SUGGESTED REGIME
Preoperative Evaluation Fasting Preoperative Medications
IV placement
SUGGESTED REGIMEINDUCTION
Preoxygenation Inform MD and RN for the readiness of induction Methohexital or others /Succinylcholine Hyperventilate until fasciculation completed Insertion of bite block or part of oral airway for tooth protection Ascertain the muscle relaxation with stimulator ECT
SUGGESTED REGIME
Emergence Hyperventilate with 100% O2 until normal vital signs obtained, then slow assisted breaths until spontaneous ventilation resumes. Turn patient on side and transport to PACU Drugs ready to use Atropine or glycopyrrolate, esmolol or labetalol, ephedrine, phenylephrine Equipment ready to use Laryngoscopes, ETT, stylet, airways, suction, defibrillator, alternative airway devices
SEVOFLURANE BST