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Environment
Water Balance &
Nitrogenous Waste
Removal
AP Biology 2006-2007
Mammalian System blood filtrate
Key functions
filtration
fluids from blood collected
includes water & solutes
reabsorption
selectively reabsorb needed
substances back to blood
secretion
pump out unwanted substances to
urine
excretion
remove excess substances & toxins
from body
AP Biology urine
Mammalian Kidney
inferior aorta
vena cava adrenal gland
kidney
nephron
ureter renal vein
& artery
epithelial
cells
bladder
urethra
AP Biology
Nephron
Functional units of kidney
1 million nephrons
per kidney
Function
filter out urea & other
solutes (salt, sugar…)
Process
blood plasma filtered
into nephron why
selective reabsorption
selective reabsorption of & not selective
valuable solutes & H2O filtration?
greater flexibility & control “counter current
AP Biology exchange system”
How can
different sections
Mammalian kidney allow the diffusion
of different
Interaction of circulatory molecules?
& excretory systems
Circulatory system Bowman’s
Proximal
tubule
Distal
capsule tubule
glomerulus = Glomerulus
ball of capillaries
Excretory system
nephron Glucose H2O Na+ Cl-
Bowman’s capsule Amino
acids H2O
H2O
Na+ Cl-
H2O
loop of Henle Mg++ Ca++ H2O
descending limb
H2O
ascending limb
collecting duct Loop of Henle
Collecting
duct
AP Biology
Nephron: Filtration
At glomerulus
filtered out of blood
H2O
glucose
salts / ions
urea
not filtered out
cells high blood pressure in kidneys
force to push H2O & solutes out of
proteins blood vessel
BIG problems when you start out
with high blood pressure in system
AP Biology
hypertension = kidney damage
Nephron: Re-absorption
Proximal tubule
reabsorbed
NaCl
active transport Na+
Cl- follows by
diffusion
H2O
glucose
HCO3- Descending
limb
Ascending
limb
bicarbonate
buffer for
blood pH
AP Biology
Nephron: Re-absorption
structure fits
Loop of Henle function!
descending limb
high permeability to
H2O
many aquaporins in
cell membranes
low permeability to Descending Ascending
limb limb
salt
reabsorbed
H2O
AP Biology
Nephron: Re-absorption
structure fits
Loop of Henle function!
ascending limb
low permeability
to H2O
Cl- pump
Na+ follows by
diffusion
Descending Ascending
different membrane limb limb
proteins
reabsorbed
salts
maintains osmotic
AP Biology
gradient
Nephron: Re-absorption
Distal tubule
reabsorbed
salts
H2O
HCO3-
bicarbonate
AP Biology
Nephron: Reabsorption & Excretion
Collecting duct
reabsorbed
H2O
excretion
urea passed
through to bladder
Descending Ascending
limb limb
AP Biology
Osmotic control in nephron
How is all this re-absorption achieved?
tight osmotic
control to reduce
the energy cost
of excretion
use diffusion
instead of
active transport
wherever possible
the value of a
counter current
exchange system
AP Biology
why
Summary selective reabsorption
& not selective
filtration?
Not filtered out
remain in blood (too big)
cells ◆ proteins