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Semiconductor nanoparticules.
Red- and green-emitting quantum dots highlight the mitochondria and nuclei, respectively, of human epithelial cells in culture. Although these colorful nanocrystals don't seem to harm the cells, could they pose unforeseen hazards to people or the environment?
Silica-coated semiconductor nanocrystals are readily incorporated into a wide variety of eukaryotic cells. In experiments where the quantum dots are deposited on a collagen substrate and then cells are deposited on top of this, the cells incorporate any quantum dots that underlie them When the cells migrate on a substrate, they ingest all the dots they pass over providing a convenient and rapid way for assessing the cells' potential to metastasize, or spread (as a cancer) from one part of the body to another [Adv. Mater., 14, 882 (2002)]. The dots appear to go into cells as "inert spectators." The cells remain healthy and even continue to divide, with each cell division reducing the number of dots in any given cell. The dots have no discernible effect on the cells. ---- A. Paul Alivisatos
Hse nano intro jty.ppt revised 05-04-04 Page No. 7
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Our study shows that, on an equal-weight basis, if carbon nanotubes reach the lungs, they are much more toxic than carbon black and can be more toxic than quartz, which is considered a serious occupational health hazard in chronic inhalation exposures. If fine NT dusts are present in a work environment, exposure protection strategies should be implemented to minimize human exposures.
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