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Stages of Digestion
Mechanical digestion is physical breakdown of food into smaller particles teeth & churning action of stomach & intestines Chemical digestion is series of hydrolysis reactions that break macromolecules into their monomers enzymes from saliva, stomach, pancreas & intestines results polysaccharides into monosaccharides proteins into amino acids fats into glycerol and fatty acids
Saliva
Functions of saliva moisten, begin starch & fat digestion, cleanse teeth, inhibit bacteria, bind food together into bolus Hypotonic solutions of 99.5% water and solutes: amylase = begins starch digestion lingual lipase = digests fat after reaches the stomach mucus = aids in swallowing lysozyme = enzyme that kills bacteria immunoglobulin A = inhibits bacterial growth electrolytes = Na+, K+, Cl-, phosphate & bicarbonate pH of 6.8 to 7.0
Swallowing
The esophagus Saliva contains salivary amylase. It hydrolyzes the glucose polymers starch and glycogen. The epiglottis blocks the top of the windpipe when we swallow. Peristalsis moves the bolus along the epiglottis.
The stomach The stomach can hold 2L of food and water. The lining of the stomach secretes gastric acid. Gastric acid contains HCl and pepsin. Pepsin is an enzyme that hydrolyzes proteins. But it breaks proteins into smaller polypeptides.
Converts ingested ferric ions (Fe+3) to ferrous ions (Fe+2) that can be absorbed & utilized for hemoglobin synthesis Destroys ingested bacteria & pathogens
Small Intestine
Nearly all chemical digestion and nutrient absorption occurs in the small intestine
Oral Cavity Salivary Amylase Polysaccharides ==> smaller Polysaccharides (starch,glycogen) (maltose)
Stomach
Small Intestine Lumen Pancreatic Amylase Polysaccharides ==> d isaccharides (maltose) Trypin, Chymotrypin Polypeptides ==> smal ler polypeptides ==> aminopeptidase, carboxypeptidase ==> Amino Acids Nucleases DNA, RNA ==> eotides ==> Brush border Disaccharidases ==> monosaccharides Dipeptidases small polypeptides ==> Amino Acids
Carbohy drates
Proteins
Nucleic Acids
Nucl
Nucelotidases ==> nuclesides ==> Nucelosidases ==> Nitrogenous bases, sugars, phosphates
Carbohydrates
Proteins
Fats
The digestive enzymes in the table below are summarized according to type of food that they digest.
ENZYME
FOOD TYPE CARBOHYDRATES
SOURCE
PRODUCTS
Maltose Maltose Glucose
Salivary amylase Salivary glands Pancreatic amylase Pancreas Maltase Small intestine Pepsin Trypsin Peptidases Lipase
PROTEINS
Stomach mucosa Peptides Pancreas Peptides Intestinal mucosa Amino acids Pancreas Fatty acids and glycerol
FATS
The table below shows digestive enzymes grouped by source of the enzyme. ENZYME SOURCE MOUTH (salivary glands) Salivary amylase STOMACH PANCREAS Pepsin Pancreatic amylase Trypsin Lipase Polysaccharides Maltose Proteins Peptides FOOD PRODUCT
Polysaccharides Maltose Proteins Peptides Fats Fatty acids and glycerol Maltose Peptides Glucose Amino acids
SMALL INTESTINE
Maltase Peptidases
Digestive function is affected by hormones produced in many endocrine glands, but the most profound control is exerted by hormones produced within the gastrointestinal tract. The gastrointestinal tract is the largest endocrine organ in the body and the endocrine cells within it are referred to collectively as the enteric endocrine system. Three of the best-studied enteric hormones are: Gastrin: Secreted from the stomach and plays an important role in control of gastric acid secretion. Cholecystokinin: A small intestinal hormone that stimulates secretion of pancreatic enzymes and bile. Secretin: Another hormone secreted from small intestinal epithelial cells; stimulates secretion of a bicarbonate-rich fluids from the pancreas and liver.
HORMON ES Gastrin
Major Activities Stimulates gastric acid secretion and proliferation of gastric epithelium
Cholecyst okin in
Stimulates secretion of pancreatic enzymes, and contraction and emptying of the gall bladder
Secretin
Stimulates secretion of water and bicarbonate from the pancreas and bile ducts
Ghrelin
Appears to be a strong stimulant for appetite and feeding; also a potent stimulator of growth hormone secretion.
Not clear, but secretion peaks prior to feeding and diminishes with gastric filling
Motilin
Apparently involved in stimulating housekeeping patterns of motility in the stomach and small intestine
Inhibits gastric secretion and motility and potentiates release of insulin from beta cells in response to elevated blood glucose concentration
Hormones and Digestion:Feedback loops.The hormone Gastrin stimulates the production of gastric acid.The pyloric sphincter regulates the release of chyme (nutrient broth) into the small intestine.Bile contains bile salts that aid digestion and absorption of fats.
Secretin hormone production is stimulated by acid chyme entering the duodenum. This hormone stimulates the pancreas to release bicarbonate to neutralize the acid. CCK stimulates the gall bladder to release bile and the panceas to release pancreatic juices. If the chyme is rich in fats causes the release of enterogastrone. This hormone inhibits peristalsis and the release of secretion of acid.
Essential Amino Acids The human liver can synthesize 9 of the 20 amino acids used in proteins. Those that cannot be synthesized are called the essential amino acids. They must be supplied by diet.
Bile Ducts and Gallbladder Definition: Bile is produced by the liver cells and collects in the small bile ducts between the microscopic liver lobules which lead to the larger ducts. Outside the liver, two outflowing hepatic ducts unite to form the common hepatic duct. From here the bile enters the cystic duct and the common bile duct . The common bile duct joins the pancreatic duct to enter the duodenum. The opening is controlled by a valve which regulates the flow of gastric juices (bile, pancreatic enzymes) into the duodenum.
Function: Bile is produced in the liver and aids the digestion of fatty food substances. Between 250 and 1000 millilitres of bile are produced each day. The most important constituents of bile are: water, bile salts, cholesterol , phospholipids . Between meals, the bile is stored in the gallbladder, which contracts once or twice as food is taken. This causes the bile to enter the duodenum via the common bile duct. 80 to 90% of the bile acids are later reabsorbed by the small intestine and re-enter the liver via the bloodstream (portal system).
Defecation
Stretching of the rectum stimulates defecation intrinsic defecation reflex via the myenteric plexus causes muscularis to contract & internal sphincter to relax relatively weak contractions defecation occurs only if external anal sphincter is voluntarily relaxed parasympathetic defecation reflex involves spinal cord stretching of rectum sends sensory signals to spinal cord splanchnic nerves return signals intensifying peristalsis Abdominal contractions increase abdominal pressure as levator ani lifts anal canal upwards feces will fall away