Final Slide Industrial Work Practice Presentation

QUALITY CONTROL PERFORMANCE FOR PHTHALATE ANALYSIS BY GAS CHROMATOGRAPHY MASS SPECTRA
Rania Fardyani 08.54.06287 SMK SMAK Bogor
Institution Profile
Phthalate
Gas Chromatography
Mass Spectrometer
Control Chart
Analytical Method
Result Discussion
Conclusion
INSTITUTION PROFILE PT SUCOFINDO (Persero) Values The Company Scopes Laboratories
Instrument Laboratory
PHTHALATE
GAS CHROMATOGRAPHY
History
1910
Mikhail S. Tswett
1930
Schuftan and Eucken
1941
Martin and Synge
1952
Gas Chromatography
1955
PerkinElmer
1959
GOW-MAC
1973
HawlettPackard (HP)
2007
Agilent Technologies
GAS CHROMATOGRAPHY
Main Definition
Gas Chromatography is a separating method by using Sample for GC liquid as stationary phase and gas as mobile pha of This method can analyze gases, of Good Factorsse. Separating Process and Indicationvolatile compounds, or easy to be volatilized.
Separation
The Advantages of GC
The Disadvantages of GC
GAS CHROMATOGRAPHY
Basic Principal
GAS CHROMATOGRAPHY
Instrumentation
GAS CHROMATOGRAPHY
Carrier Gas
GAS CHROMATOGRAPHY
Sample Injection
Direct Injection
GAS CHROMATOGRAPHY
Sample Injection
Split Injection
GAS CHROMATOGRAPHY
Sample Injection
Splitless Injection
GAS CHROMATOGRAPHY
Sample Injection
On Column Injection
GAS CHROMATOGRAPHY
Oven
GAS CHROMATOGRAPHY
Oven
Isothermal Temperature Programming
Low Temp.
High Temp.
GAS CHROMATOGRAPHY
Column
Packed Column
Capillary Column
GAS CHROMATOGRAPHY
Detector
An electronic sensor to convert the signal of carrier gas and the components within it into electronic signals.
MASS SPECTROMETER
MASS SPECTROMETER
-- - Ion Source
sample
+ + + ++ + ++
Quadropole Mass Analyzer
CONTROL CHART
Statistical Process Control
A powerful problem-solving tools and useful in achieving process stability and improving capability through the reduction of variability. Histogram Check Sheet Pareto Chart Cause and Effect Diagram Defect Concentration Diagram Scatter Diagram
Control Chart
CONTROL CHART
Control Chart
A graphical design of a quality characteristic that has been measured from a sample versus the sample number or time.
CONTROL CHART
The Function of Control Chart IMPROVE THE PROCESS
Input
Process Measurement System

Verify and follow up
Output
Detect assignable cause
Implement corrective action
Identify root cause of problem
ANALYTICAL METHOD
A1 A2 A3 A4 (BBP, DBP, DEHP, DIBP, DINP)
Vial 2 mL
GC/MS
RESULT | DISCUSSION
Phthalate Standards : 1. Diisobutyl Phthalate 2. Dibutyl Phthalate 3. Benzyl Butyl Phthalate 4. Di (2-ethylhexyl) Phthalate 5. Diisononyl Phthalate Start Date : January 2, 2012 End Date : January 12, 2012
RESULT | DISCUSSION
PARAMETER CASNUMBER STANDARD A-1 A-2 A-3 A-4 A-1 A-2 A-3 A-4 A-1 A-2 A-3 A-4 A-1 A-2 A-3 A-4 A-1 A-2 A-3 A-4 CONCENTRATION (ppm) 2.394 4.787 11.968 23.936 1.998 3.996 9.990 19.976 2.319 4.639 11.600 23.194 2.308 4.617 11.540 23.084 20.056 40.112 100.280 200.560 AVERAGE A STD/A ISTD 0.6518 1.4317 4.0382 8.4110 0.0564 0.1039 0.2853 0.6179 0.3115 0.7478 2.1429 4.8262 0.3382 0.8291 0.3726 5.5787 2.1688 5.3151 15.6758 40.1682 UCL 0.6978 1.5325 4.2832 8.9353 0.0700 0.1167 0.3120 0.6504 0.4140 0.8294 2.5221 5.3746 0.3984 0.9126 2.4775 6.1701 2.9409 6.6765 16.6987 43.6265 LCL 0.6058 1.3309 3.7932 7.8867 0.0428 0.0912 0.2587 0.5854 0.2089 0.6662 1.7639 4.2779 0.2780 0.7456 2.2677 4.9873 1.3967 3.9536 14.6530 36.7098 MAX 0.6737 1.4850 4.1099 8.5794 0.0623 0.1087 0.2964 0.6366 0.3744 0.7916 2.4189 5.1656 0.3672 0.8632 2.4204 5.8061 2.4684 5.9787 16.2198 41.2930 MIN 0.6384 1.3918 3.9064 8.1178 0.0490 0.0970 0.2695 0.6053 0.2720 0.7140 2.0403 4.5749 0.3112 0.7954 2.3099 5.1803 1.7021 4.7935 15.3427 37.9405 %RSD 2.35% 2.35% 2.02% 2.08% 8.02% 4.09% 3.11% 1.75% 10.98% 3.64% 5.90% 3.79% 5.94% 3.36% 1.47% 3.53% 11.87% 8.54% 2.17% 2.87%
Diisobutyl Phthalate
84-69-5
Dibutyl Phthalate
84-74-2
Benzyl Butyl Phthalate
85-68-7
Di (2-ethylhexyl) Phthalate
117-81-7
Diisononyl Phthalate
28553-12-0
RESULT | DISCUSSION
Parameter Inject 1 Inject 2 Inject 3 Inject 4 Inject 5 Inject 6 Inject 7 DIBP 0.9999 0.9999 0.9997 0.9998 0.9999 0.9989 0.9999 DBP 1.0000 0.9999 0.9999 0.9998 0.9987 0.9991 1.0000 BBP 0.9999 0.9997 1.0000 0.9999 0.9997 0.9999 0.9999 DEHP 1.0000 0.9998 0.9998 0.9994 0.9999 0.9972 0.9997 DNIP 1.0000 1.0000 0.9994 0.9996 1.0000 0.9996 0.9996 Parameter Inject 1 DIBP 0.9927 0.9893 0.9934 0.9876 0.9817 0.9777 0.9753 DBP 0.9899 0.9861 0.9895 0.9811 0.9772 0.9731 0.9691 BBP 0.9905 0.9856 0.9906 0.9843 0.9843 0.9746 0.9707 DEHP 0.9897 0.9841 0.9891 0.9829 0.9818 0.9725 0.9690 DNIP 0.9881 0.9816 0.9858 0.9818 0.9753 0.9697 0.9645
The Correlation of Standard Concentration to A STD/A ISTD
The Correlation of Standard Concentration to A STD
Inject 2 Inject 3 Inject 4 Inject 5 Inject 6 Inject 7
CONCLUSION
Based on the calculation, it can be concluded that the performance of GC/MS Agilent 5975 Series is still in good condition and the addition of internal standards is important in phthalate analysis by the method of GC / MS.
SUGGESTION
The maintenance needs to be done regularly to achieve the optimum conditions, such as cleaning the ion source, checking the vacuum pressure, interface, and column. Limit of Quantitation (LoQ) and Limit of Detection (LoD) of the instrument needs to be verified again so that the reading process of the analyte is stable and under control.
THANK YOU

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QUALITY CONTROL PERFORMANCE FOR PHTHALATE ANALYSIS BY GAS CHROMATOGRAPHY MASS SPECTRA

Rania Fardyani 08.54.06287 SMK SMAK Bogor

INSTITUTION PROFILE PT SUCOFINDO (Persero) Values The Company Scopes Laboratories

Quadropole Mass Analyzer

Process Measurement System

Detect assignable cause

Implement corrective action

Identify root cause of problem

A1 A2 A3 A4 (BBP, DBP, DEHP, DIBP, DINP)

Benzyl Butyl Phthalate

The Correlation of Standard Concentration to A STD/A ISTD

The Correlation of Standard Concentration to A STD

Inject 2 Inject 3 Inject 4 Inject 5 Inject 6 Inject 7

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