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45 yrs old male patient known diabetic for last 5 years and was on oral hypoglycemic agents had history of wound in the left foot for which he was taking medications. He was presented to the accident and emergency department because of extreme shortness of breath for 6hrs after which he became unconscious.
On examination there was marked hyperventilation with respiratory rate of 50 breaths /min, blood pressure was 90/40 mm of Hg , febrile and has a pussy discharging wound on the planter surface of his foot.
How will you proceed and what differentials come in your mind
ABGs
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OBJECTIVES
INTRODUCTION DIAGNOSIS CAUSES PHYSIOLOGY OF INSULIN AND DK CLINICAL FEATURES DIFFERENTIATION FROM OTHER CAUSES MANAGEMENT
INTRODUCTION
A metabolic emergency in which hyperglycemia is associated with metabolic acidosis due to greatly raised ketone levels. Dabetic ketoasidosis is usually coupled with an increase in glucagon concentration with two metabolic consequences:
Maximal gluconeogenesis with impaired peripheral utilization of glucose Activation of the ketogenic process and development of metabolic acidosis.
DIAGNOSIS
The initial step in diagnostic approach is testing urine for glucose and ketones. Diagnostic criteria for DKA:
Hyperglycemia >250 mg/dl
Ketosis (ketonemia or ketonuria) Acidosis
CAUSES:
Un diagnosed type I.
Insulin defeciency.
Known diabetic Insulin
Infection
Pneumonia UTI most commonly
Un treated newly diagnosed patient. Medical, surgical or emotional stress Use of insulin pump with leakage Drugs
Corticosterioids Thiazide diuretics
CARBOHYDRATES
GLUCOSE UPTAKE GLYCOGEN SYNTHESIS GLUCONEOGENEIS(LIVER) GLYCOLYSIS (MUSCLE)
FATS
LIPOLYSIS
PROTEIN
AMINO ACID UPTAKE (PROTEIN SYTHESIS)
POTASSIUM
K+ UPTAKE INTO CELLS
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GLUCOSE UPTAKE
AA mobilization
LIPOLYSIS
HYPERGLYCEMIA
PLASMA AA
PLASMA FFA
KETOSIS
GLYCOSURIA
GLUCOSE
ACIDOSIS
DEHYDRATION
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Increased gluconeogenesis Conversion of glycogen to glucose Inadequate use of glucose by peripheral tissues
KETOGENESIS
Occurs as a results of high glucagon/insulin ratio: Increased liberation of free fatty acids due to the loss of the inhibitory action of insulin on the hormone sensitive lipase. Beta oxidation of FFA. Decreased concentrations of malonyl coA (an inhibitor of ketogenesis)
Hyperglycemia leads to 1. Glycosuria 2. Polyuria (osmotic diuresis) 3. Polydipsia 4. Polyphagia 5. Weight loss 6. Dehyrdation Ketone bodies lead to 1. Metabolic acidosis
Ketones
Acidosis Vomiting
Renal Hypoperfusion
Average water depletion is about 5 litres Sodium depletion is 300-500 mmol Ptassium depletion is 270 400 mmol Chloride depletion is 100 400 mmol
CLINICAL FEATURES
Polydepsia Polyuria for about 24 hrs. followed by Fatigue Nausea Anorexia Vomiting Abdominal pain and tenderness. Kussmaul breathing with fruity odor acetone Signs of dehydration ( HR, postural hypotension.) low temperature. Stupor Comma Mild hypothermia
LAB FINDINGS
Glycosuria 4+ Strong ketonuria Hyperglycemia Ketonemia Low arterial pH Low Bicarbonate levels
MANAGEMENT
Therapeutic goals Improving circulatory volume and tissue perfusion
Reducing blood glucose and serum osmolality toward normal levels Clearing ketones from serum and urine at a steady rate Correcting electrolyte imbalances and identifying precipitating factors.
REMEMBER
Ensure ABC Follow standard care of unconscious patient Maintain I/V line and send samples for CBC, UCE, Blood C/S Send urine for ketones and C/S Arrange CXR and ECG Check ABGs
Send labs
Glucose. U & E. HCO3. Osmolality. Blood gases. FBC. Blood culture. Urinary ketons. Urine DR. CXR. ECG.
INSULIN REPLACEMENT
USE REGULAR INSULIN Give 0.15 Units / kg as IV bolus. Infuse 0.1 unit / kg / hr infusion or hrly I/M injection Dont use s/c insulin Maintain according to labs.
Start continuous infusion by adding 1ml(100 units) of regular insulin in 99 ml normal saline in paediatric chamber at a dose of 0.1 unit/kg /hr If the plasma glucose fails to fall by 10%in the first hour a repeat loading dose is recommended.
Rarely a pt. with immune insulin resistance is encountered, and this requires doubling the dose every 2-4 hrly if the hyperglycemia does not improve after the first two doses of insulin. Reduce the insulin infusion to 0.05 units/kg if the blood glucose falls below 200mg/dl AND OF COURSE NOT TO STOP IT!!!!
Change to s/c insulin when the pt regains consciousness and takes the meal Then start on 8 hrly sliding scale regimen for 24-48 hrs Calculate the daily requirement and then switch to fixed insulin regimen as estimated from 24 hrs requirements and dose should be adjusted according to blood glucose measurements.
FLUID REPLACEMENT
The total body deficit is about 5 litres Total fluid replacement should be about 6 litres. Failure to give adequate fluid adversely affects the outcome.
If the serum sodium is greater than 150mEq/L use 0.45% saline. Excessive fluid replacement of more than 5litres in 8 hours leads to ARDS or cerebral edema.
Use dextrose saline or 10 % dextrose when blood glucose is < 250 mg/dl and decrease the dose of insulin to 0.05 units / kg/ hr. Never stop insulin. Dextore solution prevents the development of hypoglycemia and will also decrease the likelihood of cerebral edema, which could result from too rapid decline in blood glucose.
POTASSIUM REPLACEMENT
Dont add Potassium to the first bag. Give potassium according to serum level.
< 3.0 34 45
BICARBONATE REPLACEMENT
Bicarb use in DK is questionable Give bicarb if the pH is 7.0 or less Dilute it in 5% D/W or 0.45% saline Once pH is 7.1 dont give further bicarb
BICARBONATE REPLACEMENT
Base Deficit = 0.4 x Wt. in kg (24 HCO3) Give half of the calculated deficit in first 8 hrs and the rest in next 12 hours if necessary.
BICARBONATE REPLACEMENT
E.g:
If the HCO3 is 4mEq/L in 50 kg Base decicit = 0.4 x 50 ( 24- 4)
= 0.4 x 50 x 20 = 400
BICARBONATE REPLACEMENT
PHOSPHATE THERAPY
As potassium salts
ANTIBIOTICS
Complications of DKA
Acute gastric dilatation or erosive gastritis
By vomiting blood or coffee-ground material
Cerebral edema
Obtundation Coma with or without neurological signs especially if occurring with initial improvement.
Complications of DKA
Hyperkalemia
Hypokalemia
cardiac arrest
cardiac arrythmias.
Complications of DKA
INSULIN RESISTANCE:
UNREMITTING ACIDOSIS AFTER 4-6 HRS OF RX
MI:
Chest pain Appearance of HF Hypotension despite adequate fluids
Mucormycosis:
Complications of DKA
ARDS: Hypoxemia in absence of
Pneumonia COPD HF
Vascular thrombosis:
Stroke-like picture or signs of ischemia in non nervous tissue
COUNCELLING:
We have to make sure that each patient receives intensive detailed instructions about how to avoid this potentially disastrous complication of diabetes mellitus.
SURVIVAL RULES:
Contact the Diabetic care team if: There is vomiting or diarrhea. Blood glucose stays over 380mg/dl for 3 hrs. Urine shows ketone persistantly. There are troublesome hypos.