CLASA DE ANTIBIOTICE

MACROLIDE – LINCOSAMIDE – STREPTOGRAMINE

SPECTRUL ACTIVITATII ANTIMICROBIENE

MECANISM DE ACTIUNE

REZISTENTA MICROBIANA LA ANTIBIOTICE

 MACROLIDE NEPOLIENICE

R.B. Woodward (1959) “macrolide” - genul Streptomyces

Structura
nucleu lactonic macrociclic 6-dezoxipiranozide
nesaturat polisubstituit ------ O ------ glucide - bazice (seria D)
(aglicon) beta-glicozidicã - neutre (seria L)

Activitate antimicrobianã
•bacteriostaticã – inhibarea sintezei proteice
•spectru asemãnãtor penicilinelor.
MACROLIDE NEPOLIENICE: Reprezentanti terapeutici

ERITROMICINA
Esteri PROPIONAT DE ERITROMICINA (FR X)
ETILSUCCINAT DE ERITROMICINA (FR X)
Sãruri LACTOBIONAT DE ERITROMICINA (FR X)

LAURILSULFAT DE PROPIONILERITROMICINA (estolat)

CLARITROMICINA
ROXITROMICINA
DIRITROMICINA
AZITROMICINA
OLEANDOMICINA
TROLEANDOMICINA (Ciclamicina)
SPIRAMICINA
JOSAMICINA
ERITROMICINA
 Esteri ai eritromicinei

Erythromycini propionas (FR X)

Erythromycini ethylsuccinas (FR X)

Saruri ale eritromicinei

Lactobionat de eritromicina
Glucoheptonat de eritromicina
Eritromicina
P.F.
p.o. ERITROMICINA – cp 200/250 mg; pulb. susp. 250mg/5ml
ERITROMAGIS ERITROPAR ERIVITAL (cp)
ERITROMICINA PROPIONIL – cp
ERYTHROCIN STEARAT – cp film. 500 mg
ILOSONE LIQUID (estolat) – susp.
P ERITROMICINA ETILSUCCINAT – pulb. susp.
ERITROMICINA LACTOBIONAT – pulb.inj. (+ anest. local)
 
Topic ERITROACNOL – ung. 1%
ERYFLUID, INDERM –sol.ext
ZYNERIT – sol ext
 Noile macrolide
 CLARITROMICINA

- Mai bine tolerata decat Eritromicina

+ infectii Mycobacterium avium i.c./ stadii terminale SIDA
+ UG (Campylobacter pylori= Helicobacter pylori)
Doze terapeutice= 250-500 mg/ 12 ore
Claritromicina
KLACID – compr. filmate 250mg, 500 mg C6 aglicon: -OCH3
-pulbere sterila injectabila (i.v.)
CLARITROMICINA – suspensie uz pediatric
 Azitromicina

Spectru extins asupra bacililor Gram-negativi

IT: + Mycobacterium avium / SIDA
+ difterie, tuse convulsiva
Fcinetic – distributie tisulara remarcabila;
conc i.c. crescute (fagocite);
eliminare lenta
Posologie: Doza terap= 250 mg sau 500 mg /zi , priza unica/zi x 3 zile

SUMAMED – capsule; compr. filmate; suspensie orala

ZITHROMAX- compr., suspensie orala