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6
Mechanism of action of vaccine
Use anti-idiotype antibody as
injectable vaccine
Numberof 3 2
injectionsper
dose
st
6-8weeksofage 2injectionsata
1dose 1-2month
administration interval
nd
4-6monthsof 6-12months
2dose age later
administration
8
There are two general types
INACTIVATED POLIO
VACCINE (IPV)
9
INACTIVATED POLIO VACCINE(IPV)
ep-IPV
Salk vaccine
12
Attenuatedby passage in foreign host
(monkey kidney cells)
Selection to grow in new host makes
virus
less suited to original
host
13
Differences between salk and sabin
vaccine?
Jonas Salk developed salk Albert Sabin developed
vaccine. sabin vaccine.
An inoculation dead polio An inoculation of
virus. attenuated live polio
viruses.
It is administered as an It is administrated in oral
injection. route.
Complete dose includes a 1or2 doses of oral vaccine
satisfactory immune gives 90 to 100% result.
response.
Systemic antibody Local immunity in gut.
response.
Conclusion
As the disease polio cannot be cured if
once attacked, it is better to follow
preventive measures as it is contagious.