Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
ORAL
+ - -
Metabolism Binding
Sulfonylurea
- Voltage
Insulin
Ca trigger Ca Passive
i Ca
Secretion flux
+ + Channel
Sulfonylurea
K VDCC K VDCC
ATP or ATP
Ca2+
ATP
K+ Depolarization
• DRUG INTERACTION
• Clofibrate, dicumarol, salysilates displace the
sulfonyl ureas from binding site
SECRETAGOGUE LAIN
MEGLITINIDES :
1. Repaglinide
2. Meglitinide
3. Nateglinide
BIGUANIDE (METFORMIN)
4. Liver : Hepatic
Glucose Output
Metformin HGO
METFORMIN
• DRUG INTERACTION
• Cimetidine and furosemide increased yhe metformin plasma
• Alcohol potentiate the effect of metformin
1. Intestine : glucose absorption
to digestion of carbohydrate
Improve β –
cell function
Proteins involve in glucose
lipid metabolism
mRNA
Response
elements Gene transcription
Nucleus