Gum Arabic Acacia for Manufacturing of Tablet &

pellets coating Materials.

Suad Y. Alkarib1
Dina Elraih 2
Waddah F. Nour 3
KARARY UNIVERSITY
 OPENING
Karary University is an educational
institution with military features and a
special entity.
The Head Quarter is located in
Khartoum State.
 It includes colleges, schools,
institutes and specialized training
centers.
 UNIVERSITY LAW
In January 16th 2008 Karary
University Law was approved by
the National Assembly and been
endorsed by the President in
February 18th 2008.
UNIVERSITY HEAD OFFICE
The college of pharmacy is a new college started in
2010
Vision
To see excellence in innovative pharmacy education.
 Mission
Preparation of graduates to play active role in
improvement of healthcare for Sudanese citizens and
militaries.
The first graduation is expected in 2015.
MEDICAL COLLEGES
Introduction
 Tablet is a pharmaceutical solid dosage form it is the
most preferred dosage form all over the world because
almost drug molecules can be formulated in a tablet.
Coating may be applied to solid oral dosage form
including tablets, capsules, multiparticulates and
drug crystals which coating is processed by an outer
layer of coating material which applied to the surface
of a dosage form.
Reasons of why we coat tablets :- The tablets
may be coated for a variety of reasons such as
protection of the active ingredients from air, moisture
or light, masking of unpleasant tastes and odours or
improvement of their appearance.
The aim is :- Investigation of capability of using gum
Arabic as a film former on placebo tablet (starch)
Method
4 different formulae of dried gum arabic powder
were prepared into solution
Each solution was stirred continuously for 45
minutes until completely dissolved into
homogeneous mixtures.
4 concentrations with plasticizers in ratios of 10% ,
12% , 13%, 15% gum arabic were prepared
Placebo tablets were prepared and physically
examined according to the requirement of tablets
to be coated with minimum friability and
maximum hardness, then divided into four groups
of uncoated tablets.
Each group of placebo tablet was coated with one
of the coating formula solution prepared
previously.
Physical test evaluation was then done for the
groups
Results
This shows different four groups of
coated tablets having different colour and
different film formed characteristics due to
difference in components of each formula,
hence lead to difference in results after
physical tests evaluation for the coated
samples.
Placebo
Conc. 10%
Conc. 15%
Conc. 12%
Conc. 12%
Conclusion
Combined plasticizer acts together have cross
linking job , with proper HLB (Hydrophilic
lipophylic Balance) which gives good Emulsification
power and Homogeneity.
Group A shows roughness with naked edges and
poor finishing .
Group B shows good and acceptable picture, which
is according to optimum polymer and combined
plasticizer.
Group C shows roughness and cracks on the surface
this takes place when there not enough plasticizer.
Group D shows acceptable picture .
SO
12% GUM ARABIC CONC.
IS THE FOUND TO BE THE
MOST RELIABLE
FORMULA WITH 4%
CONC. COMBINED
PLASTICIZER
Thanks for
 All of you Here
---------------Sudan my Home Country
-------------------------- Sponsors of this EVENT
 Dubai
(UAE)