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DISEASE
INTRODUCTION
Rheumatic fever
All layers of the heart and the
mitral valve become inflamed
Vegetation forms
Heart failure
JONES CRITERIA IS USED
FOR THE DIAGNOSIS
2 major or
1 major and 2 minor
Revised Jones
Criterion
Carditis
• Involves the endocardium, myocardiumand
pericardium to varying degrees
• Incidence declines with increasing age - ranging
from 90% at 3 years to around 30% in
adolescence.
• It manifest as
– Breathlessness - heart failure or pericardial effusion
– Palpitations or chest pain - pericarditis or pancarditis
– Other features include tachycardia, cardiac
enlargement
and new or changed cardiac murmurs.
– Aortic regurgitation - 50% of cases but the tricuspid
and pulmonary valves are rarely involved.
– Conduction defects
Arthritis
• Most common and
early manifestation
• Acute painful asymmetric
and migratory
inflammation of the large
joints
• Typically affects the
knees, ankles, elbows
and wrists.
• Pain
characteristically
responds to aspirin
Skin lesions
• Erythema marginatum
– occurs in < 5% of patients
– lesions start as red macules
(blotches)
that fade in the
centre
– but remain red at the edges
– occur mainly on the trunk and
proximal extremities but not the
face
• Subcutaneous nodules
– occur in 5–7% of patients
– Small (0.5–2.0 cm), firm and
painless
– Best felt over extensor surfaces of
bone or tendons
– typically appear more than 3 weeks
after - help to confirm rather than
SUBCUTANEOUS
NODULES
ERYTHEMA
MARGINATUM
Sydenham’s chorea
(St Vitus dance)
• Late neurological manifestation
• Appears at least 3 months after
the episode of ARF
• all the other signs may
have disappeared.
• Occurs in up to 1/3rd of cases
and is more common in females
• Emotional breakdown or changes
may
be the first feature.
• Typically followed by purposeless
involuntary choreiform movements
of the hands, feet or face.
• Speech may be explosive and
halting.
• Spontaneous recovery usually
occurs
within a few months
Investigations
• ESRand CRP:monitoring progress of
the disease
• Positive throat swab cultures are obtained
in only 10–25% of case.
• Echocardiography
– Mitral regurgitation with dilatation of the
mitral annulus
– Prolapse of the anterior mitral leaflet
– May also show aortic regurgitation and
pericardial effusion
Investigations