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Department of Pharmacology
Vallabhbhai Patel Chest Institute
University of Delhi, Delhi-110007
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ADR No. of Patients Percentage
Dyspepsia 13 65%
Anxiety 12 60%
Spasm of Muscles 6 30%
Insomnia 2 10%
Dizziness 2 10%
Theophylline Withdrawal Induced 1 5%
Constipation
Paraesthesia 2 10%
Others 1 5%
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V prospective, open label, randomized, parallel design
study was carried out to compare the efficacy and safety
of two methylxanthines, namely theophylline and
doxofylline in patients of bronchial asthma and COPD
anxiety
Muscle spasm
Dizziness
Sore throat
No DRs
insomnia
No DR
|
anxiety anxiety
insomnia Tremors
Gastritis Nausea
No DR No DRs
h
V Doxofylline was more therapeutically effective than
theophylline in COPD