Boala Wilson Criterii Hepatite de altă etiologie

Mutație a.r. ATP7B Cauza Virală etc.

Acută (preponderent la copii și Formele clinice Acută (adulți), cronică
persoanele tinere), cronică (debutează în copilarie)
(persoanele tinere, forma
asimptomatica poate fi
diagnosticată la oameni în
vîrsta)
Acute – clinically Semnele clinice Semnele legate cu patologia
indistinguishable from viral hepatica pot fi aceiasi.
hepatitis with jaundice,
abdominal pain, fever,
dyspepsia, nausea.
Chronic – typical symptoms of
chronic liver disease with
jaundice, edema, ascites,
esophageal varices,
teleangioectasia, bleeding,
fatigue etc.
 Boala Wilson Criterii Hepatite de altă etiologie

CNS: tremor, involuntary movements, Semnele extrahepatice Hematologic: Vasculitis (poliarteritis

difficulty swallowing (dysphagia), nodosa, cryoglobulinemia), B-Cell
difficulty speaking and poor lymphoma
articulation (dysarthria), lack of Kidney: Glomerulonephritis
coordination, spasticity, dystonic Various skin conditions
postures, and muscle rigidity. Others (rare):
Psychiatric: may vary widely, from Dementia, depression;
depression to schizophrenia, changes Myocarditis, pericarditis;
in personality or behavior. Arthritis;
Eye: Kayser-Fleischer rings Diabetes mellitus, hypothyroidism;
Blood: Coombs-negative hemolytic Various autoimmune conditions
anemia
Kidney: kidney stones, Fanconi
syndrome
Joints: Arthritis, pseudogout
Parathyroid gland:
hypoparathyroidism
Testicles: Male infertility
Heart: Cardiomyopathy
 Boala Wilson Criterii Hepatite de altă etiologie

Abnormal liver tests (ALT, AST Diagnostic Abnormal liver tests (ALT, AST
etc) etc)
+ +
Urinary copper >2 ULN; Immunological and
Serum ceruloplasmin <0.1 molecular tests:
g/l Hep.B:
Serum “free” copper AgHbs, AbHBs;
increased (total decreased) AgHBe, AbHBe;
Hepatic copper increased AbHBc IgM/IgG;
(biopsy) HBV DNA
Genetic tests confirm Hep.C:
mutation AbHCV
+ HBC RNA
Neuropsychiatric symptoms
and KF rings