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Obat Anti Influenza

Golongan Anti-Influenza
• M2 ion channel Inhibitors,
• Neuraminidase inhibitors, and
• Nucleoprotein inhibitors
M2 Ion Channel Inhibitors
Amantadine (C10H17N)
Rimantadine (C12H21N)
Mekanisme Kerja (Amantadine)
Neuraminidase Inhibitors
Oseltamivir (C16H28N2O4)
Zanamivir (C12H20N4O7)
Neuroamidase Inhibitor
Nucleoprotein Inhibitor (Favipiravir)
Favipiravir/T-705/Avigan (C5H4FN3O2)
Mekanisme kerja favipiravir. Favipiravir dikonversi menjadi
favipiravir-RTP oleh enzim sel inang dan secara selektif
menghambat aktivitas virus RNA polimerase influenza
Daftar Pustaka
1. Lagoja I M, Clercq E D. Anti-influenza virus
agents: synthesis and mode of action. 2008.
Wiley Periodicals, Inc. Med Res Rev, 28, No. 1,
1–38.
2. Furuta, Y, Gowen B B, Takahashi K, Shiraki K,
Smee D, Barnard D L. Favipiravir (T-705), a novel
viral RNA polymerase inhibitor. Antiviral Res.
2013. 1-9.
3. Ison M G, Hayden F G. Antiviral Agents Against
Respiratory Viruses. 2017. Infectious Disease. 2:
1318-1326.