Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
When the Nucleus Meet the right Magnet and radio wave
Nuclear Magnetic Resonance
2
NMR Spectroscopy
Where is it?
3
Nuclear Spin
Nuclear spin is the total nuclear angular momentum. This is characterized
by a quantum number I, which may be integer, half-integer or 0.
+ +
randomly
oriented nuclei
(no magnetic field)
E and Magnet Strength
• Energy difference is proportional to the magnetic field strength.
• E = h = h B0
2
• Gyromagnetic ratio, , is a constant for each nucleus
0T 7.05 T 11.75 T
Bo
But there’s a problem???.
If two researchers want to compare their data using magnets of different
strengths, they have to adjust for that difference. That’s a pain, so, data is
instead reported using the “chemical shift” scale as described on the next
slide.
The Chemical Shift (Also Called ) Scale
Of course, we don’t do any of this, it’s all done automatically by the NMR machine.
CH3
H3C Si CH3 Tetramethylsilane (TMS)
CH3
highly shielded.
Chapter 13
Magnetic Shielding
If all protons absorbed the same amount of energy in a given magnetic field,
not much information could be obtained.
The electrons in a bond shield the nuclei from the magnetic field.
So, if there is more electron density around a proton, it sees a slightly lower
magnetic field, less electron density means it sees a higher magnetic field
Magnetic Shielding
This represents the electron density of a C-H bond. How much electron
Z density is on the proton depends on what else is attached to the carbon. If Z
C H is an elelctronegative atom, the carbon becomes electron deficient and pulls
some of the electron density away from the H. if Z is an electron donating
group, more electron density ends up on the H.
Chapter 13
Keeping Frequency Constant
low high
field field
wo
Increase in
chemical shifts