BAGIAN DERMATOVENEROLOGY REFERAT

FAKULTAS KEDOKTERAN SEPTEMBER 2019

UNIVERSITAS PATTIMURA

PRURITIC PAPUL ERUPTION

Riqqah U Sallatalohy
NIM. 2013-83-052

Pembimbing: dr. Fitri K Bandjar, Sp.KK, M.Kes.

DIBAWAKAN DALAM RANGKA TUGAS KEPANITERAAN KLINIK

PADA BAGIAN DERMATOVENEROLOGY
UNIVERSITAS PATTIMURA
AMBON
2018
 Introduction
Pruritic papular eruption (PPE) is a form of skin
disorder that is often found in people with HIV,
especially during the advanced
immunosuppressive stage.

excoriation and skin discoloration

raises its own stigma for HIV sufferers, and will

certainly reduce the quality of life of these
sufferers
 Definition
Pruritic papules are common in HIV infection
and are due to various causes. This condition is
characterized by the presence of itching
accompanied by sterile papules or pustules that
are found on the trunk of the face, and the limbs
to varying degrees
 Epidemology
More than 50% of people infected with
HIV in some countries experience PPE at
the last stage of HIV.

the most age group is age 25-44 years

male sufferers are known to be more

numerous than females
 Etiology and patophysiology

arthropod bites drug reaction

Host cellular HIV which causes

immune response immune
that is abnormal dysregulation
 Clinical manifestation
• primary lesion: in the form of erythematous
papules with a diameter of 3-5mm, with
discrete distribution of lesions.
• 95% PPE lesions are located in the extensor
area
• urticaria papules
• intense itchingexcoriation due to scratching
• post-inflammatory hyperpigmentation,
excised prurigo and secondary infection
Clinical manifestation
Clinical manifestation
 Diagnosis
• enforced based on
clinical features
• A definitive diagnosis
of PPE can be made
based on
histopathological
features
Differential diagnosis
 Treatment
Topical steroids, emollients and oral antihistamines are still
the first-line therapy for pruritic papular eruption

UVB therapy

400 mg pentoxifylline given three times a day

The use of bed nets, insecticides can be thought of as a way to

prevent PPE

The use of anti-retroviral (ARV) is said to improve the clinical

condition of PPE
 Conclusion
• Pruritic papular eruption (PPE) is one of the
common skin manifestations in people with
HIV / AIDS infection
• the clinical picture is a discrete erythematous
papule lesion
• histopathological examination in the form of
inflammatory infiltrate consisting of
lymphocytes, and a number of eosinophils
with perivascular distribution
 Cont’
• Some conventional therapies such as oral
antihistamines, emollients, topical steroids are
considered unsatisfactory for some cases of
PPE
Thank you