Wound/Tissue Repair

Process
Chacon. Chavez. Clarin. Collado. Dimasacat.
1 NUR-1
Definition
● Wound healing is a complex and dynamic process of replacing
devitalized and missing cellular structures and tissue layers.
(Mercandetti, 2019).
● “Wound healing is a self-limited response.” (Maerib, 2016), having
the characteristics of a positive feedback mechanism. (Vanputte,
2019)
The Inflammation phase
● Tissue trauma causes injured tissue cells, macrophages, mast
cells, and others to release inflammatory chemicals.
● The white blood cells and plasma fluid which is rich in clotting
proteins, antibodies, and other substances leak into the injured
area.
● eventually forms a clot
● A scab is formed when the part of the clot that is exposed to the air
dries and hardens
The Proliferation Phase
● The wound begins to form granulation tissue (a connective tissue
composed of several elements)
● Proliferating fibroblasts within granulation tissue produce growth
factor and new collagen fibers to fill the gap
● Macrophages in our blood consume the original blood clot and
continuously create collagen fiber deposits.
● After enough growth, fibroblasts undergo apoptosis/revert to resting
stage.
The Maturation Phase
● Occurs when wound has finally closed up from the proliferation
phase
● Fibrous tissue matures and contracts, the regenerating epithelium
thickens
● This process could take up to 2 years after the wound heals
● This results in a regenerated epithelium and an underlying scar
tissue.
 Images of Effects of the Intervention
towards the Cells or Tissues

Photo Source: https://www.biodermis.com/what-are-the-stages-of-wound-healing-

s/221.htm?fbclid=IwAR0tg9_vEH2LwTdtrCID15oBFujduYw3l29buxDA8Ll_zaiaOvkkdDazVcs
Photo Source: Vanputte, C., Regan, J., Russo, A. (2019). Seeley’s Essentials of Anatomy and Physiology (10th ed.). McGraw-Hill Education, New York, NY. pp. 8, 81-91
 Relation to Topics Previously
● Superficial Wounds Discussed
and their healing process almost exclusively
deal with surface epithelium tissue.
● The process is a positive example of positive feedback, due to the
mechanics of blood clotting during healing.
● During wound healing, epithelia and connective tissues regenerate
well. Mature cardiac muscle and nervous tissue are repaired by
fibrosis. (Marieb, 2016)
Actions/Side-Effects towards the
Human Body
● Inflammation is a common occurrence during the process, as it normally
keeps the open area disinfected. However, extension of the inflammatory
phase will lead to failure of the wound to heal (Guo & DiPietro, 2010).
● Human body becomes temperature-sensitive. The optimum temperature
for wound healing is 30℃, and since lower temperatures causes
vasoconstriction, it would decrease blood flow in the area that helps
supply oxygen and nutrients to the injured area (Orsini & Divers, 2013).
Do you think cellular/histological effects of the
intervention affects the whole body? Why?
Support answer.
Yes, histological effects of the wound healing process affects the whole
body. This is because the individual components within the body are
interconnected/linked with each other in many ways. This is exemplified
in the different wound healing processes commonly seen, such as
inflammation, maturation and proliferation.
Do you think cellular/histological effects of the
intervention affects the whole body? Why?
Support answer.
In inflammation, the defense systems of the body will clump in the
infected area through blood flow to help in clotting and fighting
infections. Also, in oxygenation, the injured endothelium requires
enough amount of oxygen transported by the blood from the lungs to aid
in the creation of new tissue and maturation of the newly formed
collagen.
Based on the intervention towards the human body what can you
think will be the appropriate considerations that can be utilized by
the nurse in patient care?

The nurse’s thoughts and actions should be patient-centered. Nurses

should remember that he/she is not only treating a wound, but also a
patient who is experiencing discomfort and pain from said wound.
Nurses must assess and evaluate their patients thoroughly in order to
provide appropriate medication and treatments, as well as assess the
environment that the patient is in.
Based on the intervention towards the human body what can you
think will be the appropriate considerations that can be utilized by
the nurse in patient care?

This will allow the patient to feel more comfortable in their recovery from
their wound(s). Nurses should also value the privacy and confidentiality
of the patients, as well as show respect and compassion to the
patient(s). Especially to those who are dealing with severe pain due to
chronic wounds.
 REFERENCES
● Basehore, B., Wallace, A. & Zito, P. (2019). Wound healing phases. Retrieved from https://www.ncbi.nlm.nih.gov/books
● Guo, S., & DiPietro, L. A. (2010). Factors Affecting Wound Healing. Journal of Dental Research, 89(3), 219-
229.doi:10.1177/0022034509359125
● Haddad, L. & Greiger, R. (2019, January 19). Nursing Ethical Considerations. Retrieved from https://www.ncbi.nlm.nih.gov/books
● Kröger, K., Dissemond, J., Storck M., Risse A. & Engels P. (2012). Chronic Wounds: Hypoxia prevents healing. Wound
Management, 6(5), 212-217. Retrieved from
https://pdfs.semanticscholar.org/b7e5/98994034ab97a51c430b8c5bf505d1a20aca.pdf
● Marieb, E. N. (2016). Essential of Human Anatomy and Physiology (11th ed.). Pearson Education South Asia PTE. LTD. pp. 124.
● Mercandetti, M. (2019). Wound healing and repair. Retrieved from https://emedicine.medscape.com
● Orsini J. & Divers, T. (2013). Equine Emergencies (4th ed.). Elservier. pp. 242.
● Theoret, C. (2016). Physiology of Wound Healing. Retrieved from https://onlinelibrary.wiley.com
● Understanding the Healing Stages of Wounds. (2017, July 19). Retrieved from https://advancedtissue.com
● Vanputte, C., Regan, J., Russo, A. (2019). Seeley’s Essentials of Anatomy and Physiology (10th ed.). McGraw-Hill Education, New
York, NY. pp. 8, 81-91