World Class

Innovation Platform

///////////
National Press Foundation
September 16, 2019
St. Louis
Bob Reiter
Head of Research & Development
Crop Science Division
 Shaping Agriculture to Benefit Farmers, Consumers and Our Planet
As the Industry Leader Uniquely Positioned to Create Value and Pioneer Tailored Solutions

Our Mission
Seed & Traits

Deliver Pioneer Set new Tailored

world-class the digital standards of Solutions
innovation transformation sustainability
Digital Ag Crop
Protection
Drive operational excellence

Tailored solutions are key to sustainably managing resources and improving

productivity to feed a growing global population
2 // National Press Foundation // September 16, 2019 // St. Louis, Missouri, U.S.A.
 Unmatched Investment in R&D
Shaping the Future of Agriculture with Most Productive Innovation Platform in the Industry

2018 Ag R&D Investment ($bn)1

#1 R&D Platform in Crop Science
2.5
~7,300 R&D employees
1.3
>35 R&D sites 1.2
1.0

>175 breeding locations delivering innovation

Partner of choice Bayer Crop Corteva ChemChina Ag BASF Ag
Science

Technology provider to the industry Seed & Traits AgChem

1 Pro-forma estimates based on company information and internal calculations | Bayer Pro-forma figures consider Monsanto acquisition and related divestments

3 // National Press Foundation // September 16, 2019 // St. Louis, Missouri, U.S.A.
 Driving Data Science and Leveraging External Partnerships
Key Elements for Enabling Innovation and Effective Delivery on Industry-Leading Pipeline

Driving
‘Open Transformation
Innovation’ Model into Next Level
place ‘Open Innovation’
Driving Model
transformation in Place
towards
Data-Driven
to ensure accessR&D Organization
to external innovation next
to Ensure
level data
Access
driven
to External
R&D organization
Innovation

R&D digital vision:

Designed to ensure growers have access Technology Collaborations Customer-sponsored Research
to the best that science can offer
Build on a broad technology portfolio and
drive digital transformation across all
functions to provide novel value-adding
solutions Universities & Research Institutes

Own the industry’s leading predictive Venture Capital

pipeline informed by Artificial Bayer Growth Ventures
Intelligence
Crowdsourcing

Have 100% pipeline data connected, Grants4Targets TM

Grants4Traits TM

stored, secured and accessible in unified BLSC

platforms

4 // National Press Foundation // September 16, 2019 // St. Louis, Missouri, U.S.A.
 PROTAC® Technology in Agriculture
Bayer and Arvinas joint venture to explore cutting-edge crop protection technology

Protein degrader technology aims to New modes of action

control weeds, pests and disease in
agriculture

Potential for extremely targeted crop

protection

Potential to overcome resistance to Resistance-breaking technology

today’s crop protection solutions

5 // National Press Foundation // September 16, 2019 // St. Louis, Missouri, U.S.A.
 Breeding: Constantly Optimizing Large, Diverse Germplasm Library
Continued Investment in Data Science and New Technologies are Driving Future Opportunity

Advanced Breeding Data Science and Prescriptive Operations Product Performance Tailored Solutions
Methods Artificial Intelligence and Logistics Validation Outcome

Key parts of the Apply advanced Better logistics Prescriptive Product

pipeline are analytics to every enable innovation in planting and recommendations
protected and decision seed testing and environmental that have been field
accelerated in the product characterization to proven
greenhouse characterization maximize product
placement

6 // National Press Foundation // September 16, 2019 // St. Louis, Missouri, U.S.A.
 Well Positioned to Create Value in Ag with Genome Editing
Tools and Capabilities Build on Existing Core Competencies to Usher in New Benefits in the Next Decade

Transformative Enabling & Unlocking

Editing Tools Differentiating Competencies Opportunity

Numerous technology licenses and Germplasm Bring new products to

partnerships, including: Plant genetics central to market: improved silage quality in
leading brand positions in world-class germplasm
key crops and countries
Broad Institute
RNA-guided nucleases: Genomics
CRISPR-Cas9 and CRISPR-Cpf1 Leading genome libraries
and whole-genome
sequencing capabilities Current Improved
Pairwise Plants corn germplasm Silage edited allele

Base editing technology, which

is the next-generation of editing Testing Network Deliver future agricultural benefits,
capability Leading field testing network, including disease resistance, stress
wraps around the globe tolerance, and plant growth and
twice development

7 // National Press Foundation // September 16, 2019 // St. Louis, Missouri, U.S.A.
 Biotech: A Global Leader in Offering Farmers New Solutions
Trait Offerings Help Farmers Manage Devastation Caused by Fungal Diseases, Insect Pests and Weeds

Leadership Position

Using proprietary technology and extensive microorganism libraries to discover more

insecticidal and weed control proteins faster than ever

Focused on superior, sustainable insect and weed control solutions that are broadly
Fourth-Gen
licensed Third- Phase 2
Gen.

Sustaining and growing the base with more than 20 new and next-generation traits in
Fifth-Gen
development Phase Third-
1
Gen.

8 // National Press Foundation // September 16, 2019 // St. Louis, Missouri, U.S.A.
 Biotech: A Global Leader in Weed- and Insect-Control Solutions
Next-Generation Solutions in Corn, Soybeans and Cotton

Next Generation Biotech Weed Control Solutions Key Next Generation Insect Control Traits

Example: Soybean Herbicide Tolerance Near-Term Projects Refresh Solutions in Corn, Soy and Cotton
First biotech trait
Third-Gen Glyphosate Lygus and
for piercing and
Thrips
Phase 4 Dicamba Third-
in CottonThird- sucking insects
Glufosinate >10m acre
PhaseGen.
Gen.
4 opportunity Traited Non-traited

Glyphosate Third-Gen 3 modes-of-action

Fourth-Gen Dicamba for rootworm control
Below-Ground
Third-
Phase 2 Glufosinate in Corn Novel RNAi MoA
HPPD & another Phase Gen.
4 >100m acre
mode of action Non-Traited Traited
opportunity

Improved durability and

Fifth-Gen PPO tolerance Intacta expanded spectrum
Phase 1 added to earlier Non-
Traited
Best
2017
2 XtendThird- Additional herbicide
generation
tolerance stacks 2018 Construct
PhaseGen.
4 tolerance MoA (dicamba)
>100m acre opportunity

9 // National Press Foundation // September 16, 2019 // St. Louis, Missouri, U.S.A.
 Short Stature Corn Offers Transformational Shift in Production
Borrows from ‘Green Revolution’ Agronomic Science Pioneered by Dr. Norman Borlaug

Jerseyville, Illinois, U.S. August 2018

10 // National Press Foundation // September 16, 2019 // St. Louis, Missouri, U.S.A.
 Enhancing Processes to Identify, Optimize Small Molecule Candidates
New Safety Testing and New Screening Approaches, Combined with New Data Tools, Collectively Contribute

Additions to conventional testing cascades

Target-Based Screening Phenotyping

Find New Starting Find new starting points missed with
Direct focus on promising
Points new modes-of-action conventional screening

Biological
Screening
Conventional
approach

Increase Probability High-throughput safety testing Project specific safety testing

of Success Select against chemistries with high Drive chemical optimization towards
failure risk early in the process registrable compounds
11 // National Press Foundation // September 16, 2019 // St. Louis, Missouri, U.S.A.
 Crop Protection Innovation
Constantly improving tools for farmers in North America

Small Molecule
Biological Registrations
Registrations

CP BLX (Mon
North Only)
America 29 North

~30 ~40
EMEA 546 America 37
APAC 159 EMEA 18
LatAm 113 APAC 0
LatAm 4

12 // National Press Foundation // September 16, 2019 // St. Louis, Missouri, U.S.A.
 Delaro fungicide – innovation bringing more grain to harvest

Unbeatable broad-spectrum disease

control

Best-in-class, dual mode of action

residual efficacy

Improved Plant Health

Greener Leaves | Better Harvestability | Stress
Tolerance

Page 13 // National Press Foundation // September 16, 2019 // St. Louis, Missouri, U.S.A.
 Biologicals: Industry Leading Position
Broad Footprint, Unique Capabilities in Microbial Discovery, Characterization & Stabilization

Leadership Position Drivers

Collection of >125,000 microbial strains to leverage genetic diversity to enable product development
Focus on classical microbial products and exploring gene-editing technologies
Selected strategic partnerships include Joyn Bio, Elemental Enzymes, Novozymes

Engineered microbes enable plants to partially fulfill their nitrogen needs, offering farmers a reliable
and sustainable alternative to synthetic fertilizers.
In just 18 months, the R&D team in Boston developed microbial leads that are ready to move
into greenhouse and micro plot testing.
These “probiotics for plants” harness the power of the soil microbiome to give farmers more solutions
for crop nutrition.

14 // National Press Foundation // September 16, 2019 // St. Louis, Missouri, U.S.A.
 Biologicals
Play Key Role in Integrated Crop Solutions
BioRise™ 2 Corn Offering
Dual action bio-enhancer for United States and Canada

Biological products can increase water & nutrient uptake through the roots, and increase root
volume
Increases phosphate availability and stimulates mycorrhizal spores
Our pipeline of bio-enhancers spans geographies and crops, with frequent updates to the
commercial portfolio
15 // National Press Foundation // September 16, 2019 // St. Louis, Missouri, U.S.A.
 Key Takeaways
Shaping Agriculture to Benefit Farmers, Consumers and our Planet

1 Leading R&D platforms and pipeline frontrunner in scale and value

2 R&D supplemented with open innovation model to help enable tailored solutions

3 Optimizing large and diverse germplasm library with advanced breeding technologies

4 Leader in next-generation biotech traits; technology provider to the industry

5 Advancing new approaches in new molecule discovery – including pharma applications

6 Harnessing the natural power of biologicals

16 // National Press Foundation // September 16, 2019 // St. Louis, Missouri, U.S.A.
Appendix
///////////

R&D Pipeline
 Corn R&D Pipeline
R&D Target Technology Phase* Enhancement** R&D Target Technology Phase* Enhancement**

Br PBt CP 1 2 3 4 Dev. Subm. Br PBt CP 1 2 3 4 Dev. Subm.

YIELD & ABIOTIC STRESS DISEASE MANAGEMENT
Annual germplasm upgrades Plant Health Systems
Short Stature Corn Corn Disease Shield - Annual upgrades
Short Stature Corn 1
Acceleron - Annual upgrades
PEST MANAGEMENT Goss Wilt resistance
Chewing Pests Leaf Spots and Stem Diseases
Above Ground (Lepidoptera) New Fungicide NEW
4th generation Lepidoptera protection
WEED MANAGEMENT
5th generation Lepidoptera protection
Herbicide tolerance
Tetraniliprole 3rd generation weed management system
Belt Smart NEW 4th generation weed management system
with RHS2
Below Ground (Coleoptera)
SmartStax Pro 5th generation weed management system NEW

4th generation Coleoptera protection NEW Improved Dicamba formulations

Improved Dicamba & Glyphosate Premix
Sucking Pests
Next Generation Roundup
Stinkbug pipeline Next Generation Dicamba Premix
ARVIS
Mesotrione-Acetochlor-Dicamba Premix
Nematodes Early Pipeline
Nemastrike 2 NEW Novel PPO Herbicide
Early Pipeline
New Insecticide NEW

Progress achieved Phases 1 through 4

Br Breeding – incl. native traits and molecular breeding
Status indication for Life Cycle Management Items
*R&D Phases:
1 – Research, 2 – Early Development, 3 – Late Development, 4 – Registrations Filed PBt Plant Biotech – biotechnology traits and targeted genome optimization Strategic collaborations

Crop Protection – chemical and biological solutions applied as Represents annual advancements and upgrades
**Product enhancement: (Life Cycle Management activities) CP
seed treatment, foliar or via soil
Dev. – Under development; Subm. – Submitted for Registration Pipeline status highlighting significant development, progress
or advancement in R&D Pipeline (pink) and Key Life Cycle
Management (blue) work.
RHS2 = Second Generation Roundup Hybridization System 1 In collaboration with BASF
18 // National Press Foundation // September 16, 2019 // St. Louis, Missouri, U.S.A.
 Soybean R&D Pipeline – Peak Sales Potential: €6-7bn
R&D Target Technology Phase* Enhancement** R&D Target Technology Phase* Enhancement**

Br PBt CP 1 2 3 4 Dev. Subm. Br PBt CP 1 2 3 4 Dev. Subm.

YIELD & ABIOTIC STRESS DISEASE MANAGEMENT

Annual germplasm upgrades Soy Disease Shield NEW

High Yielding Soy1 NEW Acceleron Upgrades

Asian Soybean Rust
PEST MANAGEMENT
Indiflin NEW
Chewing Pests Fox XPro adv. to launch

INTACTA RR2 pro Leaf Spot Diseases

2nd generation insect protection New Fungicide NEW
NEW
3rd generation insect protection Early Pipeline
Belt Smart NEW New Fungicide NEW

Sucking Pests WEED MANAGEMENT

Aphid & Whitefly pipeline Herbicide tolerance

Novel Sucking Pest Solution 3rd generation weed management system
4th generation weed management system
Stinkbug Pipeline 5th generation weed management system
ARVIS New Soybean selective herbicide NEW
Improved Dicamba & Glyphosate Premix
Novel Mite Solution NEW
Improved Dicamba formulations
Nematodes Next Generation Roundup
Plant health systems WARRANT ® + Dicamba Premix
2nd generation Soy Cyst Nematode Next Generation Dicamba Premix
resistance
Podium Supra
Nemastrike 2 NEW
Early Pipeline
Novel PPO Herbicide
New Herbicide NEW

*R&D Phases: Br Breeding – incl. native traits and molecular breeding Progress achieved Phases 1 through 4
1 – Research, 2 – Early Development, 3 – Late Development, 4 – Registrations Filed
PBt Plant Biotech – biotechnology traits and targeted genome optimization Status indication for Life Cycle Management Items
**Product enhancement: (Life Cycle Management activities) Strategic collaborations
Crop Protection – chemical and biological solutions applied as
Dev. – Under development; Subm. – Submitted for Registration CP
seed treatment, foliar or via soil Represents annual advancements and upgrades

1 In collaboration with BASF Pipeline status highlighting significant development, progress

or advancement in R&D Pipeline (pink) and Key Life Cycle
Management (blue) work.
 Cereals, Oilseed Rape, Cotton, Rice R&D Pipelines
R&D Target Technology Phase* Enhancement**

R&D Target Technology Phase* Enhancement** Br PBt CP 1 2 3 4 Dev. Subm.

YIELD & ABIOTIC STRESS
Br PBt CP 1 2 3 4 Dev. Subm.
Annual germplasm upgrades
YIELD & ABIOTIC STRESS WEED MANAGEMENT
Annual germplasm upgrades 4th Generation Herbicide Tolerance
Improved Dicamba formulations
WEED MANAGEMENT
Improved Dicamba & Glyphosate Premix
Selective Herbicides
Next Generation Roundup
New Cereals Selective Herbicide NEW WARRANT® + Dicamba Premix
Atlantis franchise extensions adv. to launch Next Generation Dicamba Premix
Cereals

New Autumn Herbicides Early Pipeline

Cotton
PEST MANAGEMENT Novel PPO Herbicide
New Cereals Seed Treatment PEST MANAGEMENT
Chewing Pests
DISEASE MANAGEMENT
4th Generation Bollgard
Disease package annual upgrade
Isoflucypram NEW Sucking Pests

New Fungicide NEW Lygus & Thrips Control

New Bixafen extensions NEW Novel sucking pest solution
Delaro forte Novel Mite solution NEW
Redigo FS 25 NEW Nematodes
New Fungicidal Seed Treatment NEW Nemastrike 2 NEW
Early Pipeline
New
New Insecticide
Insecticide NEW
YIELD & ABIOTIC STRESS
DISEASE MANAGEMENT
Annual germplasm upgrades
New Fungicide NEW
Oilseed Rape

including Podshatter
WEED MANAGEMENT YIELD & ABIOTIC STRESS
DEKALB LibertyLink Canola Annual germplasm upgrades
TruFlex Canola with Roundup Ready Annual hybrid production
TruFlex Roundup Ready WEED MANAGEMENT
TruFlex Roundup Ready + LibertyLink
Council Activ adv. to launch

Rice
Dicamba-Tolerant Canola PEST MANAGEMENT
PEST MANAGEMENT Sucking Pest Tolerance
New Insecticide NEW Tetraniliprole
DISEASE MANAGEMENT Early Pipeline
New Fungicide NEW New Insecticide NEW
DISEASE MANAGEMENT
New Fungicide NEW
Super Nativo NEW