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Burden
1
Epidemiology:
Health Performance Gaps
• Prevalence
• Risk factors
– Metabolic syndrome
– Obesity
• Clinical risks of prediabetes
– Progression to diabetes
• Complications (eg, retinopathy)
2
Progression to Type 2 Diabetes
Impaired Impaired
Glucose Fasting Diabetes
Tolerance Glucose
Or both
Prediabetes
3
Prevalence of Diabetes and
Prediabetes in the United States
140
Undiagnosed DM
120 Diagnosed DM
Prediabetes 8.1 7.2
Diabetes
100 7
Persons (millions)
0
2007 2011 2014 2017
CDC. National diabetes fact sheet, 2008. CDC. National diabetes fact sheet, 2011. CDC. National diabetes statistics report,
2014. CDC. National diabetes statistics report, 2017. https://www.cdc.gov/diabetes/pdfs/data/statistics/national-diabetes-
statistics-report.pdf. 4
Prevalence of IFG and IGT in US
Adults Without T2D
NHANES 2005-2006
40
(N=1547)
34.6%
35
30
US Population (%)
25
19.4%
20
15
9.8%
10
5.4%
5
0
Prediabetes IFG only IGT only IFG and IGT
IFG, impaired fasting glucose; IGT, impaired glucose tolerance; NHANES, National Health and Nutrition Examination Survey;
T2D, type 2 diabetes.
Karve A, Hayward RA. Diabetes Care. 2010;33:2355-2359. 5