POMALIDOMIDE POMALID 4MG

| ANTICANCERDRUGS | MHP
 POMALID 4MG DEFINE

Pomalidomide is sold under the brand name Pomalid

4mg and it belongs to anti neoplastics drugs

Pomalid 4mg is doable as orally bioavailable

thalidomide derivative asssociated with numerous
therapeutic activities such as: immune modulatory, anti-
angiogenesis, anti neoplastic. Pomalid 4mg combination
with dexamethasone will cause liver injury
 POMALID 4MG CLINICAL USE

The primary indication of Pomalid 4mg

tablet is used in the treatment of Multiple Myeloma
condition. In this condition, Pomalid 4mg is used by
combining with dexamethasone. Pomalid 4mg
capsules are applicable in; Previously the Patients
treated with two treatment such as proteasome
inhibitor & Lenalidomide. Patients who are suffered
with disease progression condition Pomalid 4mg
TABLET treatment should be followed within 60 days
in patients who are concluded the last treatment.
 POMALID 4MG WORKS AS

Pomalid 4MG has three primary pharmacological

activities against cancer cells. Pomalidomide includes in the way
cancer proliferation and provoke the apoptosis of cancer cells.
Pomalidomide enhance the T cell & natural killer cells
interceding immunity & inhibits the formation of pro
inflammatory cytokines from monocytes. Pomalidomide forbid
the new cell formation. The binding of Pomalidomide to active
site of targeted cell causes inhibition of ubiquitin ligase action.
 ADME PROPERTIES

The time to high serum concentration of

Pomalidomide is reaches between 2 to 3 hours. It should be
administered with or without food. Hence No effect of food
should be produced; Volume of distribution of
Pomalidomide is between 62 & 138L in steady state.

The Pomalidomide distribution by 67% of serum level at

after 4 hours of drug intake. human plasma protein by
bounding range of 12% & 44%. Hepatically mediated
through CYP1A2, CYP3A4 is Pomalidomide is metabolized.
 ADME PROPERTIES

Pomalidomide clearance value is 7 to 10L/hr.

Doses are excreted via urine 73% & feces 15%
respectively. Doses are excreted as an unchanged
form via urine 2% & feces 8%. Pomalidomide half life
period is 9.5 hours.
 POMALID 4MG

• Brand : Pomalid
• Ingredients : Pomalidomide
• Strength : 4mg
• Manufactured : Natco
• Package : 21 TabletsDURING MULTIPLE MYELOMA
MALIGNANCIES
 DOSAGE MANAGEMENT

DURING MULTIPLE MYELOMA MALIGNANCIES

The dosage recommendation of Pomalid 4mg is
4mg should be administered as a single dose for 1 to
21 days of successive 28 day cycles. Pomalid is
combined with dexamethasone with low dose.
Administrate Dexamethasone on day 1, 8, 15 & 22 of
each 28 day cycle. The prescribed dose of
dexamethasone is 40mg should be administered the
patient having weight about ≤ 75kg. The prescribed
dose of dexamethasone is 20mg given for patient’s
weight Greater than 75kg
 DOSAGE MANAGEMENT

DOSAGE ALTERATION DURING HEMATOLOGICAL

TOXICITIES NEUTROPENIAANC
<500/mcL: Pomalid treatment should be
postponed and check the CBC weekly. ANC ≥
500/mcL: Pomalid therapy should be continued by
3mg/day For each successive drop <500/mcL:
Pomalid 4mg should be postponed. ANC ≥ 500/mcL:
Continue the Pomalid therapy with 1mg/day.
 DOSAGE MANAGEMENT

THROMBOCYTOPENIA

Platelets count <25000/mcL: Pomalid therapy

should be postponed and check CBC Platelets count
≥50000/mcL: 3mg of Pomalid should be taken daily
 DOSAGE MANAGEMENT

WITH STRONG CYP1A2

Pomalid combined with CYP1A2 substrates

causes increasing the plasma concentration of
Pomalidomide and leads to elevate the risk of
Pomalidomide.
 DOSAGE MANAGEMENT

IN RENAL DAMAGED PATIENTS

In severe renal impaired patients, the suggested

dose of Pomalid is 3mg per day.
 DOSAGE MANAGEMENT

IN HEPATIC IMPAIRED PATIENTS

The advised dose is 3mg/day & in severe

condition, the suggested dose is 2mg/day given for
mild to moderate patients.
 POMALID 4MG DRUG INTERACTION

POMALID 4MG DRUG INTERACTION

• Pomalid 4mg concurrently used with CYP1A2 drugs causes
increased concentration of Pomalidomide. Overcome this
problem by reducing the dose of Pomalid 4mg during this
combination therapy.POMALID 4MG CONTRAINDICATION

• Pomalid 4mg is contraindicated to; Pregnancy Lactation

Hypersensitivity reactions produced due to patients are
contraindicated to the component of Pomalid 4mg .POMALID
4MG WARNING

• The most probable worsening condition of Pomalid 4mg tablet

is; Venous & arterial thromboembolism Embryo fetal damage
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