Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
Dian Nurmansyah
Magister Ilmu Biomedik
Kekhususan Ilmu Kedokteran Dasar Mikrobiologi
PPs Unud
2016
Patogenesis
Viral pathogenesis is the process that occurs when a virus infects a
host.
Disease pathogenesis is a subset of events during an infection that
results in disease manifestation in the host
A virus is pathogenic for a particular host if it can infect and cause
signs of disease in that host. A strain of a certain virus is more
virulent than another strain if it commonly produces more severe
disease in a susceptible host
Viral Pathogenesis
Port de Entry, dan Replikasi Primer
Penyebaran virus dan Tropisme Sel
Kerusakan sel dan penyakit klinis
Penyembuhan Infeksi
Pelepasan Virus
Brooks, et al (2013)
LANGKAH2 PATOGENESIS
Port de entry and primer replication
Racaniello (2012)
Viral Entry in the Respiratory tract
Brooks, et al 2013
Course of Viral Infection
Primary Replication
The place of primary replication is where the virus replicates after
gaining initial entry into the host.
This frequently determines whether the infection will be localized at
the site of entry or spread to become a systemic infection.
Systemic Spread
Apart from direct cell-to-cell contact, the virus may spread via
the blood stream and the CNS.
Secondary Replication
Secondary replication takes place at susceptible organs/tissues
following systemic spread.
Penyebaran virus dan tropisme
Neural Spread
Many viruses spread from the primary site of infection by entering local nerve
ending
Hematogeneous Spread
Viruses particle may enter the blood directly through capillaries, by
replicating in endotel cell, or by a vector bite
Tropism
Tropism is spectrum of tissue infected by a virus
Tropism is governed by some paramete, it can be determined by the
distribution of :
Reseptor for entry (susceptibility)
Requirement of the virus for differently expresed intraceluller gene product
(permissivity)
Accesibility kemampuan melewati barrier host
Effect of Viruses on Cells
Steady State Persistent Infection
Infected cell
Produce and release virus but no CPE
Can grow and divide
Virus release by cell budding
Occur with several RNA viruses
Demonstrated by : Hemadsorption, direct IFT
Cytocidal Infection
Cell death and histological appearance of characteristic CPE , contohnya :
Picornavirus, Herpesvirus
Viral Protein or Virions form inclusions
Celluler Transformation
Viruses produce tumor
Virus DNA into Host DNA, alter grow and morphology (ex : HBV, HPV, EBV)
Chromosome Abnormalities
CPE (Inclusion Bodies)
Most characteristic viral morphological changes
Round or irregular, intranuclear or intracytoplasmic, acidophilic or
basophilic (terhadap penyerapan warna)
Intracytoplasmic inclusion (ICI) (most characteristic): Poxviruses,
paramyxo, Rabies
Kerusakan Sel dan Penyakit Klinis
Virus Sheeding
TERIMA KASIH