Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
Kozo Asano
Applied Microbiology, Graduate School of Agriculture,
Hokkaido University Sapporo, Japan
Why are functional foods popular in Japan?
Back grounds of functional foods.
Good Sanitation
Changing of dietary style
Advancement in medical technology,
100
80
60
40
20
0
1960 1965 1970 1975 1980 1985 1990 1995
High salt
High carbohydrate and low protein
Control
Fermented milk
Fermented milk
Fermented milk
The fermented milk was feed from 7 days baby rats everyday
with .025 to 2.5% in feeds . (Nakamura et al. 1986)
SHR: Natural mutant of High blood pressure rat
Changing blood presser in adult rats
Control
Fermented milk
(5ml/Kg)
Column chromatography
HPLC
Control
Fermented milk
Human trial Effect on higher blood presser patients
Foods, or
Drags?
Amount of substance
What must be labeled in addition to the nutrient
function claim?
450
400
350
300
250
200 FOSHU
150 Products
100
Total Sales
50 (Billion Yen)
0
1997 1999 2003
Market Size by Specified Health Use
Probiotic :
a preparations of viable microorganisms which are
added to the diet of humans to control the growth of
undesirable / less desirable microorganisms in the
gastrointestinal tract. e.g. yogurt, kefir
(%)
100
Germ-free, male
Germ-free, female
Conventional, male
Conventional, female
50
12 16 20 24 28 32 36
Months of ages
Survival curve between germ-free and
conventional animals (Gordon et al., 1966)
Bifidobacterium Bacteroides Anaerobic cocci
Representatives of cultured fecal bacteria
Lactobacillus Clostridium-other
Enterobacteriaceae
Enterococcus
Staphylococcus
Corynebacterium
Yeasts
2 3 4 5 6 7 8 9 10 11
Log no of bacteria /g feces
Intestinal tract
Liver
Choric acid
CA Choric acid
2nd. Cholate
Intake↑
Blood
Carcinogen ↓ CA
Blood cholesterol↓
LAB or Bifidobacteria
Colon cancer↓
Exostion out
6 % to total counts
5
% to total counts 4
30 3
2
25
1
0
20 B. fragilis C. clostridiiforme C. ramosum Bif. longum
15
10
0
B. vulgatus Bif adolescntis B. distasonis C aerofaciens B. thetaiotaomicron Pr. buccae
Comparison of relative prevalent bacteria in the
patients with colon cancer and healthy subjects
Healthy subjects
(by Bennno)
Colon cancer patients
Number of specimens detected
60
50
40
30
B. breve
20
B. bifidum
10 B. longum
B. adolescentis
0
Infants (70) Children (20) Adults (56) Aged persons(44)
Oligosaccharide :
a class of carbohydrates that consist of two to ten simple
sugar units joined together. Depending on the structure,
individual sugars may be cleaved off of the starting
compound by hydrolysis. see also fructooligosaccharide
Fiber :
dietary fiber is a complex mixture of plant
material that is resistant to digestion in the
human digestive tract. It can be a combination
of celluloses, hemicelluloses, pectins, gums
and lignins. See also soluble fiber, non-
soluble fiber.
Problems of FOSHU