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WELCOME

to

Sales & Marketing team meeting, 9-10 April, 2018

Overview on “Antibiotics“

Dr.H.M.Farhad MVSc
Technical Officer (resigned)

Brilliant Bio Pharma Pvt Ltd


ANTIBIOTICS
DEFINITION
What is an Antibiotic?

The medicine that inhibits the growth of (Bacteriostatic) or destroys


(Bactericidal) microorganisms mainly bacteria.

What is the use of Antibiotic?

Used to treat wide variety of infections or diseases caused by


microorganisms mainly bactiria.

How the Antibiotics are produced?

1.Biosynthesis - Produced by some microorganisms (Bacteria/Moulds)


during their growth as metabolites (eg. Penicillin).
2. Semi-Biosynthesis - Chemical compounds isolated from natural
resources used as starting material for production of Antibiotics (eg.
Ampicillin).
3. Chemical synthesis/Total synthesis - Produced by purposeful execution
of one or more named reactions (eg. Chloramphenicol) .
CLASSIFICATION OF ANTIMICROBIAL AGENTS
1.ON CHEMICAL STRUCTURE: 6 groups of antibiotics

1) Beta-lactum antibiotics (contains Beta- lactum ring in their molecular structure): Penicilllins,
Cephalosporins, etc.
2) Tetracyclines: Oxytetracyclines, Doxycyclines etc.
3) Aminoglycosides : Streptomycin, Gentamicin, Neomycin, etc.
4) Quinolones: Ciprofloxacin, Norfloxacin, etc.
5) Macrolide: Erythromycin, Azithromycin etc.
6) Sulfonamides: Sulfadiazine, Sulfamethoxazole sulfadimidin etc.

2. ON MECHANISM OF ACTION: 5 groups

1) Inhibit cell wall synthesis: Penicillin, Cephalosporin, etc.


2) Affecting permiability of cell Membrane: Polymixins, Nystatin and Amphotericin.
3) Inhibiting Prtotein synthesis affecting ribosomes: Chloramphenicol, Tetracyclines, Aminoglycosides,
erythromycin.
4) Affecting Nucleic Acid Metabolism: Rifampcin, Nalidixic Acid.
5) Affecting Metabolic Process in Bacteria: Sulphonamide, Trimithoprim, Amino salicylic Acid
3. SPECTRUM OF ACTIVITY:

Narrow spectrum Broad spectrum


Penicillin G Tetracyclines
Streptomycin Chloramphenicols

4. DEPENDING UPON THE EFFECT:

Bacteriostatic Bactericidal
Tetracyclines Pencillin
Cloramphenicol, etc. Cephalosporins, etc.
BILMOX FORTE INJ.
• COMPOSITION : 1 vial contains
• Amoxicillin sodium IP equivalent to Amoxicillin
2000 mg
• Sulbactam sodium USP equivalent to sulbactam
1000 mg
• 1 ampoule of sterile water for injection 15 ml
• Dosage and route :
• 7 to 10 mg per kg body weight, 24 hourly for 3-5
• days. In severe infections increase frequency to
12 hourly intervals
• By IV / IM / Intramammary use only
• INDICATIONS :
• Mastitis
• Urogenital infections
• Respiratory infections, Skin & soft tissue
infections
• Pre surgical prophylaxis & other
complicated bacterial infections
• PRESENTATION : 3000 mg

• SIDE EFFECTS : Allergic reactions may


be seen
BILMOX FORTE INJ.
BILCEF & BILCEF-T INJ.
* CEFTRIAXONE- third generation cephalosporin.
TAZOBACTUM- an antibacterial Pencillin derivative which
inhibits the action of bacterial beta-lactamases
* Broad spectrum bactericidal action against Gram -ve, Gram
+ve and anaerobic bacteria
* Mode of action- inhibits the mucopeptide synthesis in the
bacterial cell wall

COMPOSITION:
BILSEF 3 g vial contains Ceftriaxone sodium 3000 mg IP
BILSEF-T 3 g vial contains Ceftriaxone sodium 3000 mg IP &
Tazobactum sodium 375 mg
INDICATIONS

Wide variety of bacterial infections like


- HS disease
- Udder (Mastitis)
- Respiratory system ( Bronchitis, Broncho Pneumonia etc.)
- Urogenital system ( Vaginitis, Endometritis, Nephritis, Cystitis
retension of placenta, Dystokia etc.)
- Blood infection (Septicaemia)
- Pre & post surgical treatment
- Muskulo skeletal infections
- Otitis
- Dermatitis,
- Anaerobic bacterial infections, etc.
Dose & route:
5-10 mg per kg B.wt by IV / IM / SC routes at an
interval of 24 hrs for 3-5 days
In severe infections and advanced stages of disease it
is advisable to follow
dose of 10 mg / kg B.wt
IV OR IM route
CANINES: dose 15-25 mg per kg B.wt

The reconstituted injection should be used


immediately
Presentation:Bilcef 3g,4g Bilcef-T 562, 3375mg &4.5g
BILCEF & BILCEF-T INJ.
BILFUR INJ..
* A broad spectrum Cephalosporin active against
Gram
-ve, Gram +ve including Beta Lactamase producing
strains
* Bactericidal action by inhibiting cell wall synthesis
* Offers fastest plasma concentration
* Offers high MIC levels which will last for 24 hrs
* Can be used safely in milch animals
* Treatment applies to species cattle, buffalo, horses
sheep, goat, swine & dogs
COMPOSITION: 1 gram vial contains Ceftiofur
sodium sterile powder equivalant to ceftiofur activity 1
INDICATIONS
- Genital infections associated with Arcanobacterium
pyogens, Fusobacterium necroforum & Bacteroids
species

- Respiratory diseases associated with Pasteurella


multocida, P. haemolytica Haemophilussomnus

- Acute inter digital Necrobacillosis ( Foot rot,


Pododermatitis caused by Fusobacterium &
Bacteroids
Dose & route:
cattle, buffalo, sheep, goat :1.1 to 2.2 mg / kg B.wt
by IM route at 24 hrs interval for a period of 5-7 days
Presentation: 500mg, 1 g
Contraindications: Contraindicated in animals
previously found to be hypersensitive
Cautions: In cattle pain at injection site may be seen
Horses in stress conditions if treated may
develop severe diarrhoea, in such condition
treatment to be stoped
Withdrawl period: Milk 0 days
Meat 4 days
BILFUR INJ.
Thank You