LYME DISEASE

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1610211051
Definition

 the most common vector-borne illness in the United States, is a multisystem illness usually caused
by infection with the spirochete Borrelia burgdorferi
 And the body's immune response to the infection.] The disease is transmitted to humans via tick
bites, from infected ticks of the genus Ixodes.
 Epidemiology
 Lyme disease is endemic in North America, Europe, and Asia, and the distribution of the vectors
directly affects the incidence of the disease. Ixodes scapularis is the principal vector found in the
Northeast and Central United States and Canada, whereas Ixodes pacificus is more common on
the Pacific coast. Ixodes ricinus is the principal vector in Europe. The vector in Asia is the taiga
tick, Ixodes persulcatus.
 Etiology
 Lyme disease is usually caused by infection with the spirochete Borrelia burgdorferi (see the image
below) . The complete genome of B burgdorferi was described in 1998.
 The bacterium Borrelia burgdorferi (darkfield microscopy technique, 400X; courtesy of the US
Centers for Disease Control and Prevention). View Media Gallery
 The species Borrelia burgdorferi sensu lato has three well-characterized groups, as follows:
 B burgdorferi sensu stricto
 B garinii
 B afzelii
 Signs and symptoms
 Signs and symptoms of Lyme disease vary by disease stage. Physical findings in patients with
early disease are as follows:
 Flulike illness - Fever, chills, malaise, myalgias, arthralgia, headache
 Tender local adenopathy (local, not diffuse)
 Erythema migrans (EM) - Rash
 Physical findings in patients with early disseminated disease are as follows:
 EM (single or multiple lesions)
 Headache
 Fever
 Tender adenopathy (regional or generalized)
 Conjunctivitis (uncommon, never prominent)
 Carditis (usually manifests as heart block)
 Meningismus as a sign of aseptic meningitis
 Cranioneuropathy, especially cranial nerve VII and Bell palsy (peripheral seventh nerve palsy with
decreased unilateral function, including the forehead)
 In patients with late disease, the typical physical finding is arthritis. Arthritis is located mostly in
large joints, especially the knee. Warmth, swelling from effusion, and limited range of motion help
distinguish arthritis from simple arthralgia.
 Diagnosis
 In endemic areas, patients with probable erythema migrans and a recent source of tick exposure
should be started on treatment without blood tests. For serologic testing, the CDC recommends a
two-tier testing procedure, as follows [2] :
 Step 1: enzyme immunoassay (EIA) or immunofluorescence assay (IFA) - Total Lyme titer or IgG
and IgM titers
 Step 2: Western blot testing
 Other studies that may be used are as follows:
 Joint aspiration - To exclude other causes of effusion (eg, septic arthritis, gout, pseudogout)
 CSF analysis - In patients with meningitis
 ECG - To identify Lyme carditis
 Treatment of Lyme disease is as follows:
 Adult patients with early localized or early disseminated Lyme disease associated with erythema
migrans: Doxycycline, amoxicillin, or cefuroxime axetil
 Children under 8 years and pregnant or nursing women with early localized or early disseminated
Lyme disease: Amoxicillin or cefuroxime axetil
 Neurologic Lyme disease: IV penicillin, ceftriaxone, or cefotaxime; oral doxycycline, when not
contraindicated, in patients with Lyme-associated meningitis, facial nerve palsy, or radiculitis
 Prognosis
 The prognosis for patients with Lyme disease is generally excellent when they are treated early
with appropriate antibiotic regimens. However, recurrent infection is possible if the patient is again
bitten by an infected tick; these infections are usually due to a different strain of the
local Borrelia. [19]
 Patients, especially adults, who receive late treatment or initial treatment with antibiotics other than
doxycycline or amoxicillin may develop chronic musculoskeletal symptoms and difficulties with
memory, concentration, and fatigue. These symptoms can be debilitating and hard to eradicate.