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Disorders
Urticaria, Angioneurotic Edema,
Hereditary Angioedema
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Urticaria
Type I hypersensitive allergic reaction of
the skin
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Urticaria
Also known as hives
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edematous elevations that vary in size
and shape, itch and cause local
discomfort
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• Deep- seated swelling of tissue
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PATHOPHYSIOLOGY
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https://www.youtube.com/watch?v=d_2stYfwAog
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Causes
• Allergy- induced Urticaria
Food
Drugs (aspirin and antibiotics)
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Insect Bites (especially bees and fire ants)
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Hereditary
Angioedema
Rare, autosomal dominant genetic
disease that causes swelling of the skin
and tissue just beneath the skin. 8
TYPES
There are three forms or types of hereditary angioedema.
They are distinguished by laboratory tests and genetic testing. The disease is
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inherited as autosomal dominant gene, meaning only one abnormal gene is
required from a parent for the offspring to inherit the disease.
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SYMPTOMS
•Swelling of the skin (most common
symptom)
•Swelling of the hands and feet
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•Fatigue
•Headache
•Muscle aches
•Abdominal pain (sometimes severe)
•Nausea and vomiting
•Hoarseness
•Shortness of breath
•Mood changes
•Laryngeal edema (medical emergency)
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SYMPTOMS
• Typically begin in childhood
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and worsen during puberty
• On average, untreated
individuals have an attack
every 1 to 2 weeks, and most
episodes last for about 3 to
4 days
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CAUSES
• Autosomal dominant gene is that it
does not produce enough C1
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inhibitor (a protein that inhibits
the complement system from self-
activation) so that the body allows
fluid to escape from tiny blood
vessels into many different areas.
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