Vitis viniferae fructus

Vitis vinifera L.
Vitaceae
vita de vie

▪ stilbeni – trans-resveratrol, viniferina

150-780 μg/100 g

TRANS-RESVERATROL

80-2.700 μg/150 mL
 Itadori tea
150-780 μg/100 g
2,000 μg/200 mL
Polygonum cuspidatum
2,200 μg/g
80-2,700 μg/150 mL

~ 77 μg/100 g TRANS-RESVERATROL 86-170 μg/100 g

~ 90 μg/100 g
2.5-47 μg/28 g
19-34 μg/15 g 3.8-6.5 μg/15 g
SUPLIMENTE ALIMENTARE
trans-resveratrol

SULTs

UGTs

CYP
(1B1, 1A1, 1A2)

piceatannol
trans-resveratrol

trans-resveratrol
Slackia equolifaciens
Adlercreutzia equolifaciens
RES MET RES

25 mg 491 ng/mL (aprox. 2 μM) < 5 ng/mL (nM)

0.5 - 5 g 1.135 – 4.294 ng/mL 73 - 539 ng/mL

3.7 – 14 μmol/L 0.3 – 2.4 μmol/L
(RES-3-O-SULF)

370 – 1.735 ng/mL

0.92– 4.3 μmol/L
(RES-3-O-GLC,
RES-4'-O-GLC)

in vitro : > 1000 ng/mL

> 5 μmol/L
1 g RES / zi, 4 sapt.

• statine
 CYP 3A4 • antagonisti ai canalelor de calciu
• antiaritmice
• ciclosporina A

RES-3-O-SULF – lipsa inhibitiei (50 μmol/L)

 CYP 2C9 • losartan

 CYP 2E1
Vaccinii fructus
Vaccinium macrocarpon L.
Ericaceae
cranberry

▪ flavonoide – proantocianidoli tip A, antociani

  CYP 3A4  CYP 2C9

warfarina

suc de cranberry + warfarina → INR > 50 (deces prin hemoragie interna)

CYP 3A4 antibiotice macrolide (eritromicina, claritromicina)
statine (atorvastatin, lovastatin)
benzodiazepine (midazolam, alprazolam)
blocante ale canalelor de calciu (verapamil,diltiazem)
agenti anti HIV (indinavir, ritonavir)
progesteron, chinidina
CYP 2C9 antagonisti de receptor ai angiotensinei II (losartan)
AINS (ibuprofen, suprofen)
propranolol, montelukast
CYP 2C19 antidepresive (imipramina, clomipramina)
inhibitori ai pompei de protoni (omeprazol, pantoprazol)
Punicae granati fructus
Punica granatum L.
Lythraceae
rodie

▪ taninuri hidrolizabile – punicalagine

 CYP 3A4  carbamazepina

 CYP 2C9  tolbutamida

 sulfotransferaze
Mali fructus
Malus domestica Borkh. (M. pumila)
Rosaceae
mar

▪ ac. fenolici, flavonoide, triterpene

cvercetol
ideain
3.69-3.86 mg/100 g
 OATP (OATP2B1, OATP1A2)

Statine (rosuvastatin)
beta-blocante (atenolol)
Antibiotice (eritromicina)
antivirale
agenti antitumorali
fexofenadina
fexofenadina (60 mg) + 300 mL suc,
apoi 150 mL suc la fiecare 30 min. timp de 3 h

 fexofenadina cu 79%

atenolol (50 mg) + 300 mL suc,

apoi 900 mL si 300 mL suc

 atenolol cu 86%
 CYP1A1
activarea metabolica a unor pro-carcinogeni
(hidrocarburi policiclice aromatice – benzo(a)piren)
 ► ALTE INTERACTIUNI MEDICAMENT - ALIMENT

ANTIHISTAMINICE - ALCOOL

bromfeniramin clorfeniramin clemastina (Tavegyl)

cetirizina levocetirizina fexofenadina
desloratadina (Clarinex)

alcoolul potenteaza starea de somnolenta indusa de aceste

antihistaminice
ANAGEZICE / ANTIPIRETICE - ALCOOL

acetaminofen (paracetamol)

alcoolul potenteaza efectul hepatotoxic al paracetamolului

ANTIINFLAMATOARE NESTEROIDIENE - ALCOOL

aspirina diclofenac
ibuprofen (Paduden, Rupan, Advil)
ketoprofen naproxen celecoxib (Celebrex)

alcoolul creste riscul de aparitie a hemoragiilor digestive

BRONHODILATATOARE - ALCOOL

teofilina (Miofilin) albuterol (Salbutamol, Ventolin)

alcoolul potenteaza efectele secundare

(greata, varsaturi, migrena, iritabilitate)

BRONHODILATATOARE - CAFEINA

teofilina (Miofilin) albuterol (Salbutamol, Ventolin)

cafeina potenteaza efectele secundare

(excitabilitate, nervozitate, tahicardie)
INHIBITORI AI ENZIMEI DE CONVERSIE A ANGIOTENSINEI -
ALIMENTE BOGATE IN K

captopril enalapril lisinopril

quinapril (Accupril) ramipril (Altace)

banane portocale legume cu frunze verzi

suplimente cu K

alimente / suplimente cu K potenteaza hiperkaliemie indusa de inhibitorii

enzimei de conversie a angiotensinei (agenti antihipertensivi) 
ritm cardiac neregulat
palpitatii
STATINE - ALCOOL

simvastatina lovastatina atorvastatina

alcoolul potenteaza efectele hepatotoxice ale statinelor

ANTIANGINOASE (NITRATI) - ALCOOL

nitroglicerina isosorbid dinitrat (Isoket)

alcoolul potenteaza efectele vasorelaxante ale nitratilor 

scadere pronuntata a tensiunii arteriale
ANTICOAGULANTE CUMARINICE -
ALIMENTE BOGATE IN VITAMINA K

warfarina (Coumadin) acenocumarol (Trombostop, Sintrom)

broccoli varza napi

varza de Bruxelles spanac

 diminuarea eficacitatii anticoagulantelor cumarinice

ANTICOAGULANTE CUMARINICE -
USTUROI, GHIMBIR, SUPLIMENTE BE BAZA DE GINKGO BILOBA

 cresterea riscului de hemoragii interne

LINEZOLID - ALIMENTE BOGATE IN TIRAMINA

lactate maturate, procesate

preparate din carne maturate, procesate
avocado
banane
fructe uscate
ciocolata (exces)
bauturi alcoolice

 crize hipertensive