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Components of Innovative
Therapeutics
• Metabolic Syndrome X
• Inflammation
• Oxidative Stress
• Toxic Lipogenesis
• Energy regulation
• Thermogenesis
REDEFINING SYNDROME X
• Classic Definition: Obesity,
Hypercholesterolemia, High
Blood Pressure, Linked by
Insulin Resistance.
• Syndrome X, Y and Z….., an
expanded definition
incorporating a novel unifying
concept of common diseases
THE PUBLIC HEALTH RISK
• Syndrome X increases risk for :
Type II Diabetes Mellitus
Cardiovascular Disease
Cardiovascular Deaths
Deaths from ALL CAUSES
Am.J.Epidemiol, 148, 958, 1998.
INTEGRATIVE MEDICINE FOR
SYNDROME X
Holt S, et al
Effect of
Gel Fiber…
Lancet,
March 24th,
1979.
Thermogenesis
• The process of generating heat in the
animal body (Citrus, Seaweed, etc)
• Classic thermogenics include amines that
increase metabolic rate, a function of
beta-3 receptor activity which also
induces lipolysis and amino acid uptake
in muscle eg ephedrine and synephrine
• These classic amines tend to have non-
specific adrenergic receptor function with
cardiovascular stimulatory effects.
• Ma Haung, Citrus peel and Advantra Z
Citrus Aurantium Extract With Standardized
p-Synephrine Content, Patented and
Researched in Weight Control as Advantra Z
Advantra Z
• This extract of Citrus aurantium (bitter
orange peel) is thermogenic, lipolytic,
ergogenic, mood enhancing, appetite
suppressing and it promotes muscle
building (Peel off the Weight, HIOM 2009)
• A body of evidence indicates that Advantra
Z does not cause the same degree of
cardiovascular or CNS hyper stimulation
that led to the withdrawal of Ephedra
Advantra Z
• Gougeon et al. (Obesity Research,
13, 2005, 1187) described an
increase in the thermic effect of food
(TEF) by amines isolated from Citrus
aurantium
• TEF increased by 29% in women
without effects on blood pressure or
pulse rate, but with measurable
increase in epinephrine excretion
UNREALISTIC
WEIGHT LOSS
EXPECTATOIN
A LITANY OF NEW PERSPECTIVES:
2010
• Clarification of the epidemiology of
obesity.
• Fat cell regulation of energy balance
• Neuro-hormonal control of appetite.
• Fuel sensing by the CNS.
• Obesitis
• Insulin Resistance: Syndrome X
• Cancer propagation
• Drug and nutraceutical approaches
CONCLUSIONS
• There is no successful, sustainable stand
alone intervention for weight control
• Failing to manage Metabolic Syndrome X
and its associated disorders (Syndrome X,
Y, Z…) in the overweight person is
tantamount to negligence.
• Sleep, oxidative stress, inflammation,
nutrition, exercise, behaviour modification
and detoxification are therapeutic targets.
• The “Multipronged Approach” to weight
control must be favored.