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STEPHEN HOLT, MD, ChB., DSc, LLD (Hon.), PhD, ND,


FRCP(C) MRCP (UK), FACP, FACG, FACN, FACAM,
OSJ, Distinguished Professor of Medicine,
(Scientific Advisor to Natural Clinician, LLC)
     
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SUMMARIZING BIOPHYSIOLOGICAL
EFFECTS OF CALORIE RESTRICTION
u Suppression of inflammatory
responses
u Hormetic effects
u Inhibition of glycolysis with insulin
sensitizing actions
u Genetic regulation e.g. Sir2 or
human homologous SIRT1g
FOR THE SKEPTIC

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CONCEPTS OF CALORIE
RESTRICTION MIMETICS (CRM)
u V CRM is an agent that has the ability to
reproduce one or more of the principal
biological effects of calorie restriction
(Weindruch, R, et al. J.Geront, 56, 20-33 2001).
u Many CRM of pharmaceutical or natural origin
induce substantially similar bio-physiological
changes that are documented with prolonged
dietary calorie restriction, in many species.
CRM IN ANTI-
ANTI-AGING THERAPEUTICS
u Synergistic combinations of natural
substances with Calorie Restriction Mimetic
properties have been identified and
combined for a nutritional approach to
longevity.
u Examples of CRM: Metformin, Resveratrol,
Carnosine, Gymnema, Vlpha Lipoic Vcid,
Cinnamon, Vvocado, OPCs (grape seed),
Ellagic Vcid, N-Vcetyl-Carnitine, Green Tea

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A NATURAL CRM SUPPLEMENT DEVELOPED
BY HOLT MD LABS FOR NATURAL CLINICIAN

u Carnosine u OPCs (grape


u Resveratrol seed)
u Gymnema u Ellagic Vcid
u Vlpha Lipoic Vcid u N-Vcetyl-
u Cinnamon Carnitine
u Vvocado u Green Tea
  
A PROTOCOL FOR NUTRITION
AND LONGEVITY
u Calorie restriction of a tolerable degree
combined with natural calorie restriction
mimetics.
u Maintenance of nutrient density by the use
of mixed fruit, vegetable and greens powders
containing minerals and full RDI of vitamins
u Extra mineral enrichment
u Obsessional detection and treatment of
Syndrome X (70 million Vmericans)
THE SYNDROME X BRIGADE
TELOMERES AND TELOMERASE
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TELOMERES

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TELOMERES AND TELOMERASE
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SAFE TELOMERE SUPPORT OR LENGTHENING

u Many factors alter telomere length e.g. age,


sedentary lifestyles, chronic inflammation,
oxidative stress, hormonal deficiencies and
abnormal glucose metabolism.
u Single agents that may increase the activity of
telomerase have been proposed for use as
dietary supplements to support telomere
length (Vstragalus) but safety issues exist.
SAFE TELOMERE SUPPORT OR LENGTHENING:
THE TELOMERE SUPPORT PROTOCOL
u Initial telomere testing
u Positive lifestyle change
u Dietary adjustments
u Meticulous disease management e.g. Syndrome X
and Diabetes mellitus
u Miscellaneous interventions: reduction of
cardiovascular risk factors, control of
inflammation, exercise programs, hormone
supplementation
u Nutrient, botanical and herbal supplements
NUTRACEUTICAL INTERVENTION FOR
TELOMERE LENGTHENING
u Synergistic safe combinations of the following
agents is optimal: Chinese Ginger Root, Gingko
biloba, N-Vcetyl-L-Cystine, vitamins B12, D3, E,
Nicotinamide, and Folic acid
u Peer-review medical literature supports the
above nutrient composition and the use of
omega 3 fatty acids from enteric coated fish oil.
u Extracts of Vstragalus that directly induce
telomerase activity to lengthen telomeres
cannot be considered to be safe.
Many Stem Cell Types
Reproduced from SA Biosciences, Pathways, 2009
Stem Cell Therapies:
Disadvantages and Limitations
u Embryonic Stem Cells, Embryonic Germ Cells
and Fetal Tissue Stem Cells pose major ethical
and moral problems which cannot be resolved.
u Cord Blood and Placental Stem Cells pose
unresolved technical problems, e.g. survival.
u Vdult Stem Cells remain an imperfect
therapeutic procedure, except bone marrow.
u Induced Pluripotent Stem Cells (Yamanaka,
2006) hold promise
Adult Stem Cells
u Vdult Stem Cells (VSC) live in niches in
most organs and they can migrate.
u They are tethered in niches by adhesion
molecules that determine cell migration
and niche retention. Compounds that
interfere with adhesion factors may
mobilize VSC.
u Most information is known about Human
Bone Marrow Vdult Stem Cells.
A Novel and New Stem Cell Strategy in
Integrative Medicine Practice: Induced
Adult Stem Cell Recruitment (IASCR)
u Induced Vdult Stem Cell technologies involve
the stimulation of endogenous stem cells to
regenerate or heal diseased or ailing tissues.
u Many compounds of natural or
pharmaceutical origin may play an active role
in the proliferation of human Vdult Stem
Cells or cells carrying markers CD34+ and
CD133+ (Jensen GS et al, 2002 and Bickford P
et al, 2006, Holt S, 2008).
The Concepts of IASCR: Part 1
u Mobilize Vdult Stem Cells from bone
marrow and other niche locations (?)
u Increase circulation of VSC with a
semicontinuous, safe stimulus. Herbs,
botanicals and nutrients are preferred to
drug approaches (cost, side effects)
u Protect stem cells from oxidative damage
u Encourage homing to desired target organ
The Concepts of IASCR: Part 2
u Vssistance in the differentiation of Vdult
Stem Cells to replace cell types of the
diseased organ has to be developed.
u V body of research demonstrates that
human bone marrow Vdult Stem Cells
are able to ͞home in͟ on diseased organs
and differentiate into many cell types
(Egletis, 1997 and Korbling et al, 2002).
Factors that Mobilize Stem or
Progenitor Cells
u DRUGS (or isolated biologicals in clinical use
or trials): IL1, IL3, IL6, Stem Cell Factor (s),
erythropoetin, G-CSF etc.
u NUTRACEUTICALS : oleic acid, linolenic acid,
blueberry, blue-green algae (VFV), green tea,
fucoidan and vitamin D3. Putative releasers or
antioxidant protection with fucoxanthin, beet
root, spirulina, spinach, ashwagandha, grape
seed extract. Cofactors Vit B12, Folate
In Vivo Release of ASC
(Data from Stemtech Inc. on AFA)

AFA increases CD34+ Stem Cells cf placebo


THE ANTI-
ANTI-AGING TRILOGY
Stephen Holt MD, 2010

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CONCLUSIONS: THE ANTI-
ANTI-AGING TRILOGY
u Research and the application of technology to
achieve the favorable outcome of calorie restriction,
telomere support and stem cell treatments is
proceeding at a rapid pace. Natural approaches exist.
u The Naturopath has a variety of botanicals, herbs
and nutrients that have an evidence base to support:
1. Bio-physiological changes that occur with calorie
restriction. ͞Calorie Restriction Mimetics͟
2. Telomere support ͞Clinical Telomere Support͟
3. Stem cell mobilization and potential recruitment