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Proposal Defense:
‘’NUMERICAL ANALYSIS OF EPIDEMIC MODELS’’
Presented By
TAHIRA QAYYUM
MS-MATHEMATICS
Supervisor:
Dr. Shoaib Arif
Co-Supervisor:
Dr. Syed Ahmed Pasha
Department of Mathematics
Air University, Islamabad Pakistan
2
Outline
INTRODUCTION
OBJECTIVES
LITERATURE REVIEW :
Selected paper 1
Selected paper 2
PERFORMANCE METRIC
METHODOLOGY
PRELIMINARY WORKk
3
Introduction (1/3)
4
Introduction (2/3)
An epidemic model comprises compartments for example
Susceptible: The susceptible population who are not affected but
are at risk for infection.
Infectious: Infected and able to transmit the infection to other
susceptible individuals
Immune: Individuals who have either recovered and gained
permanent immunity from the disease SI S I
S – Susceptible
SIS S I S
I – Infectious
R - Removed
SIR S I R
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Introduction (3/3)
The assumptions are
• Population is fixed
• Infectious period = disease duration
• After recovery, individuals are immune
• The rate at which the total number of susceptible individuals become infected is
proportional to the product of susceptible and infected individuals
6
Objectives
7
Literature Review(1/6)
8
Literature Review(2/6)
SELECTED PAPER-1
Objective:
To study epidemic models on complex networks
9
Literature Review(3/6)
SIR epidemic model
Assuming a large population size N
𝑁 = 𝑁 𝑆 + 𝑁𝐼 + 𝑁𝑅
𝑁𝑠 𝑆 𝑁
𝑖
𝐼 𝑁
𝑟
Define = 𝑁 , = 𝑁 , = 𝑁 𝑅 are fraction of susceptible, infected and recovered individuals
𝑁 𝑁 𝑁
So
𝑁 𝑆 + 𝑁𝐼 + 𝑁𝑅 = 1
dNS Β Infectious Rate
= −βNS NI (1)
dt γ Recovered Rate
dNI
= βNS NI − ϒNI (2) 𝑁𝑆 Susceptible Individuals
dt
dNR 𝑁𝐼 Infected Individuals
= ϒNI (3)
dt 𝑁𝑅 Recovered Individuals
10
From (1)
1 dNS
NI =− (4)
βNS dt
From (3)
I 1 dNR
N = (5)
ϒ dt
1 𝑑N S 1 𝑑𝑁 𝑅
− =
𝛽N S 𝑑𝑡 ϒ 𝑑𝑡
1 dNS β dNR
=−
NS dt ϒ dt
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Integrating both sides w.r.t ‘’t’’
β
ln N S − ln N0S = −
ϒ
β R
S − ϒ N
NS = N0 e
As N I = 1 − N R − N S
substituting in (3)
dt 1
=
dN R −
βNR
ϒ 1 − N R − N0S e ϒ
1 1
t= βNR
d𝑅
ϒ −
1−NR −NS0 e ϒ
12
Literature Review(4/6)
SIS epidemic model
𝑑NS
= ϒ𝑁 𝐼 + 𝛽N S 𝑁 𝐼 (6)
𝑑𝑡
𝑑𝑁𝐼
= 𝛽N S 𝑁 𝐼 − ϒ𝑁 𝐼 (7)
𝑑𝑡
Substituting N S = 1 − 𝑁 𝐼 in (7)
𝑑𝑁𝐼
− 𝛽 − ϒ 𝑁 𝐼 = −𝛽 𝑁 𝐼 2 (8)
𝑑𝑡
Bernoulli’s differential eq. is
𝑑𝑁𝐼
+ 𝑝 𝑡 𝑁 𝐼 = 𝑓 𝑡 (𝑁 𝐼 )𝑛
𝑑𝑡
Let 𝑁 𝐼 = 𝑢1−𝑛 = 𝑢 −1
𝑑𝑁𝐼 𝑑𝑁𝐼 𝑑𝑢
=
𝑑𝑡 𝑑𝑢 𝑑𝑡
Substituting in (8)
𝑑𝑢
−𝑢−2 − 𝛽 − ϒ 𝑢−1 = 𝛽𝑢−2
𝑑𝑡
𝑑𝑢
+ 𝛽−ϒ 𝑢 = 𝛽 (9)
𝑑𝑡
Which is linear differential eq.
So integrating factor= 𝑒 𝛽 −ϒ 𝑑𝑡 = 𝑒 𝛽−ϒ 𝑡
Eq.(9) becomes
𝑒 𝛽−ϒ 𝑡 𝑑𝑢 + 𝛽 − ϒ 𝑢𝑒 𝛽−ϒ 𝑡 = 𝛽𝑒 𝛽−ϒ 𝑡
𝑑𝑡
𝑑
𝑢𝑒 𝛽−ϒ 𝑡 = 𝛽𝑒 𝛽−ϒ 𝑡
𝑑𝑡
Integrating both sides
𝛽−ϒ 𝑡 𝑒 𝛽−ϒ 𝑡
𝑢𝑒 = 𝛽 + 𝐶1
𝛽−ϒ
𝛽 (𝑒 𝛽−ϒ 𝑡 +C)
𝑢=
𝛽−ϒ 𝑒 𝛽−ϒ 𝑡
1 1
𝐴𝑠 𝑁 𝐼 = ⇨𝑢=
𝑢 𝑁𝐼
ϒ 𝑒 𝛽−ϒ 𝑡
𝑁𝐼 𝑡 = 1−
𝛽 𝑒 𝛽−ϒ 𝑡 +C
14
Literature Review(5/6)
SELECTED PAPER-2
Objectives:
16
Stochastic Epidemic Model (6/6)
𝑁 𝐼 𝑡 , 𝑁 𝑅 (𝑡) ∊ {0,1,2…….N}
𝑁 𝑠 𝑡 = 𝑁 − 𝑁𝐼 𝑡 − 𝑁𝑅 𝑡
17
Stochastic epidemic model (6/6)
N I + 1, N R with probability
βN I N s ∆t + O ∆t
I R
N I − 1, N R + 1 with probability
N ,N →
δN I ∆t + O ∆t
NI , NR with probability
1 − βN I + δN I ∆t + O ∆t
18
Methodology
19
Performance Metric
β
R0=
γ
20
Preliminary Work
Demonstrate the numerical techniques. Consider the SIR epidemic modelwe discretize
(1) and (2) by using
Forward Euler discretize model:
𝑁𝑆 𝑖+1 −𝑁𝑆 𝑖
From (1) = −𝛽𝑁 𝐼 𝑖 𝑁 𝑆 𝑖
∆𝑡
𝑁 𝑆 𝑖+1 = 𝑁 𝑆 𝑖 − ∆𝑡 𝛽𝑁 𝐼 𝑖 𝑁 𝑆 𝑖
𝑁𝐼 𝑖+1 −𝑁𝐼 𝑖
From (2) = 𝛽𝑁 𝐼 𝑖 𝑁 𝑆 𝑖 − ϒ𝑁 𝐼 𝑖
∆𝑡
𝑁 𝐼 𝑖+1 = 𝑁 𝐼 𝑖 + ∆𝑡 𝛽𝑁 𝐼 𝑖 𝑁 𝑆 𝑖 − ϒ𝑁 𝐼 𝑖
21
Initial conditions 𝐍𝟎𝐒 = 𝟒𝟎, 𝐍𝟎𝐈 = 𝟏𝟎
22
Initial conditions 𝐍𝟎𝐒 = 𝟒𝟎, 𝐍𝟎𝐈 = 𝟏𝟎
23
Results
24
Thank You
25