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• Cycles of smooth muscle contraction and relaxation are associated
with spontaneous cycles of depolarization and repolarization
known as slow wave potentials (or simply slow waves)
• Slow wave frequency varies by region of the digestive tract,
ranging from 3 waves/min in the stomach to 12 waves/min in the
duodenum.
• Current research indicates that slow waves originate in a network
of cells called the interstitial cells of Cajal (named for the Spanish
neuroanatomist Santiago Ramón y Cajal), or ICCs.
• These modified smooth muscle cells lie between smooth muscle
layers and the intrinsic nerve plexuses, and they may act as an
intermediary between theneurons and smooth muscle
Secretions of GIT