Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
Clotting Process
Formation of a blood clot (thrombus) in blood vessels or the
heart.
May be life saving (when it plugs a severed vessel) or life-
threatening if it occludes a vessel supplying a vital structure.
May break loose to create an embolus that flows downstream
to lodge at a distant site.
The potential consequence is ischemic necrosis of cells and
tissues known as infarction.
Cerebral vascular accidents (stroke), myocardial infarction and
pulmonary embolisms are examples of disorders resulting from
thrombosis or embolism.
Classification of Coagulant
(i) Calcium salts
(ii) Vitamin-K / Vitamin-K1 / Phytomenadione (Natural)
(iii) Vitamin-k3 / Menadione (Synthetic)
Synthesis of Warfarin
Synthesis of Phenindione
Synthesis of Ticlopidine
Synthesis of Dipyridamole
Adverse Effects of Heparin
Prostaglandin synthesis
ADP binding
Adverse Effects
GI upset
Bleeding
Drug-induced thrombocytopaenia
Blood dyscrasias
Adverse Effects of Fibrinolytics
Bleeding
Allergic reactions
Hypotension
Arrhythmias
Re-perfusion injury