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◼ Foods and nutrients can alter the absorption, metabolism, and excretion of nutrients of drugs.
Suppress appetite, alters taste sensations, induce nausea or vomiting, cause mouth dryness, or create
inflammation or lesions (mouth stomach, or intestinal lining).
◼ Side effects
◼ abdominal discomfort, constipation, and diarrhea
◼ If not resolved, will cause weight loss or malnutrition
◼ Can also cause weight gain
◼ Avoid treatment
◼ Appetite advancers prescribed in certain cases
DRUGS ALTER NUTRIENT ABSORPTION
◼ Some antibiotics bind to calcium in foods & supplements, which reduces absorption of both
substances.
◼ iron, magnesium, & zinc may also bind to antibiotics
◼ dairy and supplements hours after medication
◼ Medications that reduce stomach acidity may interfere with absorption of vitamin B12, folate, & iron.
◼ Several drugs interfere with intestinal metabolism or transport into mucosal cells.
DIET-DRUG TOXICITIES
◼ Warfarin (Coumadin) - Vitamin K
◼ Coumadin - foods that affect blood
viscosity
◼ Insulin, Oral Diabetic Agents, - Alcohol
◼ Digoxin, High-Fiber Diets, and Herbs
◼ Statins - grapefruit
◼ Calcium Channel Blockers - grapefruit
◼ Erectile Dysfunction Drugs - grapefruit
◼ Acetaminophen - alcohol
◼ Antibiotics - dairy products
◼ MAOIs and Tyramine - Containing
Foods
◼ Antithyroid Drugs and Iodine-Rich
Foods
THE INACTIVE INGREDIENTS IN DRUGS
◼ Grapefruit juice reduces the bioactivation of prasugrel, but it has a limited effect on the antiplatelet
effect of the drug.
◼ prasugrel: acts as a platelet inhibitor, and is used to prevent blood clotting.
Food-Drug Interactions: Barbara Mendez. R. Ph. M.S. Registered
Pharmacist & Nutritionist
References
◼ Barbara Mendez (2015, May 18). YouTube Retrieved from https://www.youtube.com/watch?v=8WwHOqmXozo
◼ Bushra, R., Aslam, N., & Khan, A. Y. (2011). Food-drug interactions. Oman Medical Journal, 26(2), 77–83. doi:10.5001/omj.2011.21
◼ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191675/
◼ Holmberg, M. T., Tornio, A., Hyvärinen, H., Neuvonen, M., Neuvonen, P. J., Backman, J. T., & Niemi, M. (2015). Effect of grapefruit
juice on the bioactivation of prasugrel. British Journal of Clinical Pharmacology, 80(1), 139–145. doi:10.1111/bcp.12581
◼ RD, C. M. B. (2016). Dangerous food-drug interactions. December 12, 2016, Today’s Geriatric Medicine,
http://www.todaysgeriatricmedicine.com/archive/101308pe.shtml
◼ Whitney, E. N., & Rolfes, S. R. (2007). Understanding nutrition, ISE (11th ed.). United States: Thomson Higher Education.