Journal Reading

ASTHMA
 Treatment
1. Avoidance of allergens/ irritants
2. Pharmacological interventions
Inhaled medication delivery devices
 Conservative
Follow up should include:
• Reviewing the asthma action plan
• Observation of inhaler device technique
• smoking cessation
• monitor growth velocity and potential corticosteroid side effects
• Screening for signs and symptoms of adrenal suppression
• Allergies
• Refer to an asthma specialist

Criteria for assessing asthma control

• No exacerbations
• Fewer than 3 doses/week of a rapid-acting beta2- agonist bronchodilator
• Daytime symptoms < 3 days/week
• No nighttime symptoms
• Normal physical activity
• No absenteeism from work or school
• FEV1 or PEF at least 90% of personal best
 Reliever medications

• SABAs (short-acting beta2-agonists)

SABAs should only be taken on an as needed basis for
symptom relief
• LABAs
• Short-acting anticholinergic bronchodilators, such as
ipratropium bromide (second-line therapy)
These agents appear to be less effective than inhaled rapid-
acting beta -agonists and, therefore, should be reserved as
2

second-line therapy for patients who are unable to use SABAs.

 Controller medications
• Inhaled corticosteroids (ICSs)
Low-dose ICS monotherapy is recommended as first-line
maintenance therapy for most children and adults with asthma.
• Combination ICS/LABA inhalers
LABA monotherapy is not recommended in patients with asthma
as it does not impact airway inflammation and is associated with
an increased risk of morbidity and mortality.
Four combination ICS/LABA inhalers are available in Canada:
fluticasone propionate/salmeterol, budesonide/formoterol,
mometasone/formoterol and fluticasone furoate/vilanterol (see
Table 7).
• Leukotriene receptor antagonists
The LTRAs, montelukast and zafirlukast, usually reserved for patients who are unwilling or
unable to use ICSs, be used as add-on therapy if asthma is uncontrolled despite the use of low-
to-moderate dose ICS therapy or combination ICS/LABA therapy.

• Long-acting muscarinic receptor antagonists

The LAMA, tiotropium, can be used as add-on therapy for patients with a history of
exacerbations despite treatment with ICS/LABA combination therapy.

• Theophylline
Theophylline is an oral bronchodilator with modest anti inflammatory effects.

• Biologic therapies
The anti-IgE monoclonal antibody, omalizumab, reserved for patients with difficult to control
asthma who have documented allergies, an elevated serum IgE level
• Systemic corticosteroids
Systemic corticosteroids, such as oral prednisone, are generally used for the acute treatment of
moderate to severe asthma exacerbations.
Pediatric dose information adapted from BCGuidelines.ca Guidelines & Protocols Advisory Committee, 2015 [31] ICS inhaled corticosteroid, pMDI
pressurized metered-dose inhaler, DPI dry powder inhaler, LTRA leukotriene receptor antagonists, IgE immunoglobulin E, IL-5 interleukin 5, bid twice
daily, sc subcutaneously, IV intravenously, LABA long acting beta agonist, LAMA long-acting muscarinic receptor antagonist, po oral, prn as needed
 Indications for referral

1. Atypical asthma symptoms or diagnosis of

asthma is in question
2. The patient has poor asthma control
3. The patient requires a detailed assessment
4. The patient has been admitted to the
intensive care unit (ICU) for asthma.
 SUMMARY

Asthma is respratory disorder and for diagnosis should be should be

suspected in patients with recurrent cough, wheeze, chest tightness and
dyspnea, and should be confirmed using objective measures of lung
function (spirometry preferred). Allergy testing is also recommended
to identify possible triggers of asthma symptoms. Asthma can be
achieved using avoidance measures and appropriate pharmacological
interventions. All patients with asthma should have regular follow-up
visits during which criteria for asthma control, adherence to therapy
and proper inhaler technique should be reviewed.