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( Pantothenic Acid)
Vitamin B5 ( Pantothenic Acid)
It is a peptide composed of D-Pantoic acid and β-Alanine
and is found as calcium salt or as alcohol
(Pantothenol). The biologically active form of Vitamin
B5 is coenzyme A (CoA).
RDA: 7-10 mg (4 Years and over)
3-5 mg (less than 4 Years)
Principal Sources in Food
Principal dietary sources of vitamin B5 include:
Food Serving size mg
Calf liver 100 g 7.9
Pea nuts 100 g 2.6
Pantothenic acid
Peas 100 g 2.1
Soybeans 100 g 1.9
Brown rice 100 g 1.7
lobster 100 g 1.7
Water melon 100 g 1.6
Egg 1, Avg size 0.9 Pantothenol
Brewer’s Yeast 10 g 0.7
Functions of vitamin B5
Pantothenic acid is a part of CoA that acts as an intracellular
carrier for few carbons-groups and assists more than 100
pathways of intermediate metabolism including those of:
1. Synthesis of Sterols (Cholesterol and 7-
Dehydrocholesterol), Fatty acids, and Keto-
acids such as Pyruvic acid.
2. Energy production
3. Synthesis of vitamins A and D.
4. Biosynthesis of protein and amino acid by assisting
the formation of leucine, arginine, and
methionine.
5. It is essential for the formation of hemoglobin
and electron-carrying cytochrome proteins of
the mitochondrial respiratory chain.
6.Biosynthesis of the neurotransmitter acetylcholine.
Symptoms of Vitamin B5 Deficiency
1.Paresthesias (It is a sensation of tingling,
pricking, or numbness of a person's skin)
and burning sensation in lower legs and
feets.
2. Joint and muscle aches
3. Fading of hair color
4. Anemia
5.Reduced immunity: impaired antibody response
6. Headache, depression, insomnia, and fatigue
9. Dexapantothenol (vitamin B5
Formulation) is used topically in
treatment of burns and itching .
Vitamin B6
(Pyridoxine)
Vitamin B6 (Pyridoxine)
In 1934, a Hungarian physician, Paul Gyorgy
discovered a substance that was able to cure a skin
disease in rats (Dermititis acrodynia), this
substance he named vitamin B6.
Vitamin B6 converted in the body to its major active form:
pyridoxal-5-phosphate (PLP). The activation
requires adequate zinc and riboflavin.
Total body stores of vitamin B6 are low (only about 150
mg) hence a steady supply of vitamin B6 is essential
to avoid its deficiency.
Chemically it is a pyridine derivative.
RDA
1.2 – 1.4 mg (Adult)
0.6 mg (Infants less than 1 year)
2.2mg (During pregnancy and lactation)
Pyridoxol Pyridoxal
Potatoes
Banana
Calf liver
Trout Spinach
Lentils
Functions of Vitamin B6
PLP is a coenzyme involved in more than 100 metabolic
reactions in the body including:
Protein synthesis through interconversion of amino acids.
Conversion of tryptophan to niacin.
It helps in maintaing blood glucose within a normal
range. When caloric intake is low, vitamin B6 help to
convert stored carbohydrate to glucose to maintain
normal blood sugar levels.
Lipid metabolism: It is important in synthesis of lipids of
myelin sheath surrounding nerves and also in
production of polyunsaturated fatty acids of cell
membranes.
It helps in hemoglobin synthesis and oxygen transport by
red blood cells.
Symptoms of Vitamin B6 Deficiency
Skin disorders: Dermatitis (skin inflammation), Stomatitis
(inflammation of the mucous lining of any of the
structures in the mouth), Glossitis (is inflammation or
infection of the tongue ), and Painful fissures and
cracks at the angles of the mouth and on the lips.
Abnormal brain-wave patterns, convulsions, and muscle
twitching.
Depression, irritability, anxiety, confusion, headache, and
insomnia.
2. Atherosclerosis:
Folate help preventing atherosclerosis (heart attack,
and peripheral vascular disease) in people with
elevated homocysteine (THF with Vitamin B12
detoxify homocysteine to methionine).
4. Psychiatric/nervous disorders:
Symptoms of dementia in elderly people may be
improved by folic acid supplementation. Folate
can be adjunctive therapy with lithium in the
treatment of manic- depressive illness.
Folic Acid – Drug Interactions
D C
Vitamin B12
5. The central metal ion is cobalt (Co) which
coordinates with nitrogens of corrin ring and that
of dimethylbenzimidazole group.