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Mechanisms: Regulation
- Module 4: PART 1 -
Outline
Building/
maintainin
g body
Energy
usage
Signals from body and brain
Local theories (Cannon and Washburn, 1912)
• Signals controlling hunger are produced in the peripheral organs of
the body
• Based on experiments in which Washburn swallowed balloons which
were inflated – saw that stomach wall movement (from balloon)
triggered feelings of hunger
• Problem: Vagus nerve connects stomach and brain, but when cut –
hunger still experienced
Central theories
• Brain detects changes in body’s state and triggers appropriate
motivations to keep body in homeostatic state
• Key region: Hypothalamus, connected to many brain regions, controls
critical autonomic nervous system functions, pituitary gland, endocrine
system, detect changes in blood components
Hypothalamus: specialized
subcomponents
• Appetite NTs
• neuropeptide Y
• α-MSH
Short-term regulation continued…
• Controlled by glucose sensitive system
• But, not just central nervous system receptors in
VMH and LH
• Accomplished by the duodenum and/or liver
• Evidence they control hunger and satiety
• Changes in glucose levels here alter eating
behaviors lab studies
• Influenced by the level of cholecystokinin
(CCK) in the blood
• Secreted by upper intestine in response to
presence of food
• Sends signal to brain to stop eating