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  • Thyroid Physiology in Pregnancy

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    Thyroid Physiology in Pregnancy

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    ppt

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    Thyroid Physiology In Pregnancy

    EFFECTS OF PREGNANCY ON THYROID


    PHYSIOLOGY

    Physiologic Change Thyroid-Related Consequences


    ↑ Serum thyroxine-binding globulin ↑ Total T4 and T3; ↑ T4 production
    ↑ Plasma volume ↑ T4 and T3 pool size; ↑ T4
    production; ↑ cardiac output
    D3 expression in placenta and (?) uterus ↑ T4 production
    First trimester ↑ in hCG ↑ Free T4; ↓ basal thyrotropin; ↑ T4
    production
    ↑ Renal I- clearance ↑ Iodine requirements
    ↑ T4 production; fetal T4 synthesis during
    second and third trimesters
    ↑ Oxygen consumption by fetoplacental ↑ Basal metabolic rate; ↑ cardiac
    unit, gravid uterus, and mother output
    hCG
    TSH
    Physiologic Changes in Thyroid Function
    During Pregnancy

    Maternal TSH Free T4 Free


    Thyroxine
    Total T4 Total T3 Resin
    Triiodo-
    Status **initial Index thyronine
    screening (FTI) Uptake
    test** (RT3U)

    Pregnancy No No No Increase Increase Decrease


    change change change

    Hyperthyroidism Decrease Increase Increase Increase Increase Increase


    or no
    change

    Hypothyroidism Increase Decrease Decrease Decrease Decrease Decrease


    or no
    change
    Thank You

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